The percutaneous fate of the rodenticide flocoumafen in the rat: role of non-biliary intestinal excretion

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
K R HuckleP A Warburton


1. Appreciable penetration of radioacticity occurred through rat skin following percutaneous administration of 14C-flocoumafen. At 7 days after dosing 12% of the administered radioactivity remained at the site of application, while 25% was located in the liver as unchanged flocoumafen. 2. Excretion of flocoumafen metabolites via the urine accounted for 10% dose over the 7 day experiment, this is some 30-fold greater than that seen after a single oral dose. 3. Unchanged flocoumafen comprised the major product detected in faeces. Biliary elimination was a very minor route of excretion and did not account for all of the unmodified flocoumafen present in faeces. 4. Considerable amounts of unchanged flocoumafen found associated with the contents of the large intestine after intraperitoneal administration to rats fitted with biliary fistulae indicates that, in the intact rat, flocoumafen enters the intestine by a non-biliary intestinal excretion mechanism.


Jul 1, 1975·Journal of Pharmaceutical Sciences·W D ConwayL Neufeld
May 1, 1979·Clinical Pharmacology and Therapeutics·J J BoylanP S Guzelian
Dec 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K R HuckleP A Warburton
Jan 1, 1985·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·K Rozman
Mar 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L T Wong, G Solomonraj


Apr 28, 2007·Cutaneous and Ocular Toxicology·Milena KataranovskiMilena Jovic
Jul 2, 2005·Toxicology·Milena KataranovskiIvana Majstorović
Jan 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K R HuckleC J Logan

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