The performance of (1, 3)-beta-D-glucan and Aspergillus galactomannan measurement for early diagnosis of invasive aspergillosis in patients with hematological diseases

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Yuji Horiguchi

Abstract

We analyzed the performance of (1, 3)-Beta-D-glucan (measurement by the alkaline-kinetic chromogenic Limulus method (FUNGITEC G test-MK, Fungitec) and the kinetic turbidimetric Limulus method [Beta-Glucan test WAKO, Wako]) and we carried out Aspergillus galactomannan antigen detection (enzyme-linked immunosorbent assay, ELISA test) for the early diagnosis of invasive aspergillosis in patients with hematological diseases at the time of febrile episodes of unknown origin that did not respond to antibacterial therapy for more than 3 days. During a one-year period (April 2002 to March 2003), a total of 69 febrile episodes in 58 patients were studied; 8 cases of invasive aspergillosis were diagnosed according to the definition of the European Organization for Research and Treatment of Cancer/Mycosis Study Group, and 61 cases were found to be non-mycotic diseases. Based on the analysis of 69 results with confirmed disease status, the overall performance of the Fungitec, the Wako, and the ELISA test were as follows: sensitivity was 0.88, 0.63, and 0.50, respectively, whereas the specificity was 0.85, 0.98, and 1.0, respectively. Moreover, there was a strong relationship between the log-transformed values of the (1, 3)-Beta-D-glucan le...Continue Reading

Citations

Nov 15, 2007·Current Infectious Disease Reports·L Joseph Wheat
Aug 3, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A KedzierskaJ Kedzierska
Jul 1, 2009·Expert Opinion on Medical Diagnostics·Cornelia Lass-Flörl, Astrid Mayr
Dec 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshikatsu OkudaKazunobu Takayanagi
Aug 18, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L J Wheat
Jul 22, 2020·The Cochrane Database of Systematic Reviews·Sandra K WhiteKimberly E Hanson

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