The performance of acute versus antecedent patient characteristics for 1-year mortality prediction during intensive care unit admission: a national cohort study.

Critical Care : the Official Journal of the Critical Care Forum
Monika C KerckhoffsDiederik van Dijk

Abstract

Multiple factors contribute to mortality after ICU, but it is unclear how the predictive value of these factors changes during ICU admission. We aimed to compare the changing performance over time of the acute illness component, antecedent patient characteristics, and ICU length of stay (LOS) in predicting 1-year mortality. In this retrospective observational cohort study, the discriminative value of four generalized mixed-effects models was compared for 1-year and hospital mortality. Among patients with increasing ICU LOS, the models included (a) acute illness factors and antecedent patient characteristics combined, (b) acute component only, (c) antecedent patient characteristics only, and (d) ICU LOS. For each analysis, discrimination was measured by area under the receiver operating characteristics curve (AUC), calculated using the bootstrap method. Statistical significance between the models was assessed using the DeLong method (p value < 0.05). In 400,248 ICU patients observed, hospital mortality was 11.8% and 1-year mortality 21.8%. At ICU admission, the combined model predicted 1-year mortality with an AUC of 0.84 (95% CI 0.84-0.84). When analyzed separately, the acute component progressively lost predictive power. From ...Continue Reading

References

May 7, 2002·Critical Care Medicine·Sean P KeenanJohn J Spinelli
Apr 13, 2006·Chest·Kevin B LauplandDanny J Zuege
Apr 25, 2008·Critical Care Medicine·Teresa A WilliamsSteven A R Webb
Feb 27, 2010·British Journal of Anaesthesia·T A WilliamsUNKNOWN Royal Perth Hospital ICU Data Linkage Group
Mar 4, 2010·JAMA : the Journal of the American Medical Association·Hannah WunschWalter T Linde-Zwirble
Apr 18, 2013·Critical Care Medicine·Sylvia BrinkmanNicolette F de Keizer
Nov 28, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sean M BagshawSumit R Majumdar
Jul 12, 2014·Intensive Care Medicine·Allan GarlandRandall Fransoo
Nov 8, 2014·Critical Care Medicine·Jeremy M KahnUNKNOWN ProVent Study Group Investigators
Nov 17, 2015·Critical Care Medicine·Vivek K MoitraHannah Wunsch
Nov 29, 2015·International Journal of Epidemiology·Nick van de KlundertNicolette F de Keizer
Jan 28, 2016·American Journal of Respiratory and Critical Care Medicine·Nazir I LoneTimothy S Walsh
Apr 3, 2016·Critical Care : the Official Journal of the Critical Care Forum·A D HillD C Scales
Apr 15, 2016·Critical Care Medicine·Daren K HeylandUNKNOWN Canadian Critical Care Trials Group and the Canadian Researchers at the End of Life Network
May 12, 2016·The New England Journal of Medicine·Jill I CameronUNKNOWN Canadian Critical Care Trials Group
Jun 7, 2016·Critical Care : the Official Journal of the Critical Care Forum·M BagshawH Tom Stelfox
Aug 3, 2016·Journal of Critical Care·Ian M BallIan G Stiell
Dec 7, 2016·American Journal of Respiratory and Critical Care Medicine·Nathan E BrummelE Wesley Ely
May 17, 2017·Critical Care : the Official Journal of the Critical Care Forum·James S KrinsleySean M Bagshaw
Jul 6, 2017·Intensive Care Medicine·John MuscedereKenneth Rockwood

❮ Previous
Next ❯

Citations

Oct 20, 2020·Journal of Critical Care·Michael BeilP Vernon van Heerden
Jun 6, 2021·Intensive Care Medicine·A M HigginsUNKNOWN PREDICT Study Investigators

❮ Previous
Next ❯

Software Mentioned

R ( Statistical Environment Package )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.