The performance of three estimates of glomerular filtration rate before and after live donor nephrectomy

Transplant International : Official Journal of the European Society for Organ Transplantation
Adam D BarlowMichael L Nicholson

Abstract

Serum creatinine-based estimates of glomerular filtration rate (GFR) are inaccurate in healthy individuals. Therefore, their use in assessment prior to live donor nephrectomy has been restricted. There are less data on their use postdonor nephrectomy. This study assessed three GFR estimates against Cr(51) EDTA radioisotope GFR (iGFR) in the same cohort of patients before and after donor nephrectomy. A total of 206 patients underwent iGFR measurement prior to donor nephrectomy and this was repeated in 187 patients 6-8 weeks postsurgery. The iGFR was compared with the modification of diet in renal disease (eGFR), Cockcroft-Gault (cgGFR) and Mayo Clinic equation (mcGFR) estimates of GFR. Preoperatively, all GFR estimates performed poorly against iGFR; however, mcGFR provided the most reliable estimate. The eGFR underestimated iGFR by 23.60 +/- 16.43 ml/min/1.73 m(2), cgGFR by 15.54 +/- 18.13 ml/min/1.73 m(2) and mcGFR overestimated by 0.72 +/- 18.11 ml/min/1.73 m(2). Postdonation, all estimates again performed poorly, but eGFR and mcGFR outperformed cgGFR. The eGFR underestimated iGFR by 9.13 +/- 10.11 ml/min/1.73 m(2), mcGFR by 9.44 +/- 13.80 ml/min/1.73 m(2) and cgGFR overestimated by 6.42 +/- 14.49 ml/min/1.73 m(2). No GFR esti...Continue Reading

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Citations

Nov 19, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ann YoungUNKNOWN Donor Nephrectomy Outcomes Research (DONOR) Network
Jan 22, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Rachid YakoubiJihad H Kaouk
Mar 19, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ali KhalilAsif Sharfuddin
Mar 20, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ali KhalilAsif Sharfuddin

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