PMID: 8601335Mar 1, 1996Paper

The perinuclear microtubule-organizing center and the synaptonemal complex of higher plants share a common antigen: its putative transfer and role in meiotic chromosomal ordering

Chromosoma
A C SchmitA M Lambert

Abstract

Recognition of homologous chromosomes during meiotic prophase is associated in most cases with the formation of the synaptonemal complex along the length of the chromosome. Telomeres, located at the nuclear periphery, are preferential initiation sites for the assembly of the synaptonemal complex. In most eukaryotic cells, telomeres cluster in a restricted area, leading to the "bouquet" configuration in leptotene-zygotene, while this typical organization progressively disappears in late zygotene-pachytene. We wondered whether such striking changes in the intranuclear ordering and pairing of meiotic chromosomes during the progression of prophase I could be correlated with activity of the centrosome and/or microtubule-organizing center (MTOC). Plant cells may be used as a model of special interest for this study as the whole nuclear surface acts as an MTOC, unlike other cell types where MTOCs are restricted to centrosomes or spindle pole bodies. Using a monoclonal antibody (mAb 6C6) raised against isolated calf centrosomes we found that the 6C6 antigen is present over the entire surface of the plant meiotic nucleus, in early prophase I, before chromosomal pairing. At zygotene, short fragments of chromosomes become stained near the...Continue Reading

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Citations

Jun 8, 2000·Microscopy Research and Technique·J CanadayA C Schmit
Jun 12, 2002·Molecular Biology of the Cell·Wen-Hui ShenPascal Genschik
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·R. Kelly Dawe
Jan 11, 2008·The Journal of Biological Chemistry·Takateru NakayamaKoichi Mizuno
Jan 1, 2010·The Arabidopsis Book·Iris Meier, Jelena Brkljacic
May 4, 2006·Annual Review of Plant Biology·Olivier HamantW Zacheus Cande
Feb 26, 2000·Annual Review of Genetics·D Zickler, N Kleckner
Aug 1, 2004·The New Phytologist·Federica BrandizziDavid E Evans

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