The perioperative use of ceftriaxone as infection prophylaxis in neurosurgery

Clinical Neurology and Neurosurgery
J Z ZhaoK C Lau

Abstract

An open label study was conducted in the department of neurosurgery, Beijing Tiantan Hospital in China to determine the incidence of postoperative infections following the use of one or two doses of ceftriaxone administered perioperatively. A total of 343 patients, who required neurosurgery and had satisfied the inclusion criteria, was recruited during a 12 month study period. Of these 343 patients, there were 97 and 107 cases of malignant and benign tumours, respectively, 52 cases of aneurysm, 34 cases of arteriovenous malformation, and 53 other cases who underwent neurosurgery for drainage of sub-dural haematoma, relief of cerebral oedema and other indications. A total of 6 (1.75%) cases of postoperative infection was observed, of which 4 were found in the malignant tumour group, and 2 in the arteriovenous malformation group. All six patients were suffering from meningitis. During the 12 month period immediately prior to the present study, when postoperative penicillin and gentamicin was administered twice daily for 5-7 days as regular prophylaxis against infection, the incidence of postoperative infection was 7.2% in the same department managed by the same staff. Results of our present study suggest that one to two doses of ...Continue Reading

References

Oct 1, 1979·Annals of Internal Medicine·P Newfield, M F Roizen
Jul 1, 1988·Journal of Neurosurgery·R DempseyP Tibbs
Aug 1, 1988·Journal of Neurosurgery·G C Blomstedt, J Kyttä
Nov 1, 1986·American Journal of Surgery·J T DiPiroJ A Mansberger
May 1, 1986·Antimicrobial Agents and Chemotherapy·G BenoniA Lechi
Apr 9, 1987·The New England Journal of Medicine·R S SchwalbeP H Gilligan
Jan 1, 1985·Canadian Anaesthetists' Society Journal·J F Mayhew, S Deutsch
Jun 23, 1973·British Medical Journal
Feb 1, 1983·Antimicrobial Agents and Chemotherapy·R W SteeleJ Spicehandler
Jan 1, 1983·Chemotherapy·F D DaschnerH G Hillemanns
Jan 1, 1984·Chemotherapy·H M JustF D Daschner
Dec 1, 1984·The Journal of Antimicrobial Chemotherapy·B Wiedemann, M Kresken
Jan 1, 1982·Journal of Neurosurgery·S J Haines, M L Goodman
Jan 1, 1981·Chemotherapy
Jun 1, 1981·Neurosurgery·G R Quartey, K Polyzoidis
Aug 1, 1980·Antimicrobial Agents and Chemotherapy·M SeddonR Livingston
Aug 1, 1951·The Australian Journal of Dentistry·G KAYE

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