The peripheral blood immune cell profile in a teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia

Journal of Neuroimmunology
Maria Rosa CiardiClaudio Maria Mastroianni

Abstract

A teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia was hospitalized and recovered in 15 days. The immunophenotyping analysis of peripheral blood cells was performed in two time points: the first was 1 month before (pre-infection) while the second was during COVID-19 pneumonia (infection). At the infection time point, no differences in the percentages of immune activation and immunesenescence of CD4+ and CD8+ T-cells were observed compared to the pre-infection time point. Our evaluation seems to confirm that teriflunomide controls T-cells immune activation and immunosenescence suggesting that teriflunomide should not be discontinued in MS patients with an active COVID-19 pneumonia.

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Citations

Oct 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tobias ZrzavyThomas Berger
Jan 12, 2021·Multiple Sclerosis and Related Disorders·Fioravante CaponeVincenzo Di Lazzaro
Feb 13, 2021·Multiple Sclerosis and Related Disorders·Maryam Sharifian-DorchePaul Steven Giacomini
Feb 22, 2021·Journal of Neurology·Fioravante CaponeVincenzo Di Lazzaro
Jun 16, 2021·Multiple Sclerosis and Related Disorders·Geraldine LueticUNKNOWN on behalf RelacoEM Study group
Sep 7, 2021·Neurodegenerative Disease Management·Aaron E Miller
Nov 2, 2021·Frontiers in Immunology·Gaëlle TillyNicolas Degauque

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Methods Mentioned

BETA
X-ray
flow cytometry

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