The peripheral immune response of mice infected with a neuropathogenic schistosome

Parasite Immunology
Martin MajerPetr Horák

Abstract

Trichobilharzia regenti (Schistosomatidae) percutaneously infects birds and mammals and invades their central nervous system (CNS). Here, we characterized the peripheral immune response of infected mice and showed how it was influenced by the parasite-induced inflammation in the skin and the CNS. As revealed by flow cytometry, T cells expanded in the spleen and the CNS-draining lymph nodes 7-14 days post-infection. Both T-bet+ and GATA-3+ T cells were markedly elevated suggesting a mixed type 1/2 immune response. However, it dropped after 7 dpi most likely being unaffected by the neuroinflammation. Splenocytes from infected mice produced a high amount of IFN-γ and, to a lesser extent, IL-10, IL-4 and IL-17 after in vitro stimulation by cercarial homogenate. Nevertheless, it had only a limited capacity to alter the maturation status of bone marrow-derived dendritic cells (BMDCs), contrary to the recombinant T. regenti cathepsin B2, which also strongly augmented expression of Ccl5, Cxcl10, Il12a, Il33 and Il10 by BMDCs. Taken together, mice infected with T. regenti developed the mixed type 1/2 immune response, which was driven by the early skin inflammation rather than the late neuroinflammation. Parasite peptidases might play an...Continue Reading

References

Feb 1, 1988·Immunological Reviews·C M SnapperW E Paul
Jan 23, 1999·Journal of Immunological Methods·A FreyD Zurakowski
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F R FischerM E Dorf
May 23, 2002·Journal of Helminthology·K Hrádková, P Horák
May 22, 2002·The Journal of Experimental Medicine·Hiroyuki YoneyamaKouji Matsushima
Oct 14, 2003·Microbes and Infection·Anahí ChavarríaEdda Sciutto
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pavlína KourilováAdrian P Mountford
Sep 16, 2006·Immunological Reviews·Monica J CarsonCorinne C Ploix
Mar 22, 2007·PloS One·Benoit FoligneCorinne Grangette
May 29, 2008·European Journal of Immunology·Yongpeng GuHuabao Xiong
May 5, 2009·The Journal of Allergy and Clinical Immunology·Chiara NembriniManfred Kopf
Oct 14, 2010·Folia Microbiologica·J HrdýL Prokešová
May 3, 2011·Medical Microbiology and Immunology·Avantika VermaRakesh K Gupta
May 11, 2011·Experimental Parasitology·Lucie LichtenbergováPetr Horák
Oct 5, 2012·Clinical Microbiology Reviews·Henry J McSorley, Rick M Maizels
Oct 11, 2012·Journal of Helminthology·J Finsterer, H Auer
Jan 12, 2013·Trends in Parasitology·Miroslava SoldánováBernd Sures
Jan 9, 2015·Clinical Microbiology Reviews·Petr HorákSara Vanessa Brant
Jan 28, 2015·Infection and Immunity·Catriona T PrendergastAdrian P Mountford
Mar 22, 2015·Current Opinion in Immunology·Judith E AllenDominik Rückerl
Sep 24, 2015·Clinical and Experimental Immunology·Asiel Arce-SillasLaura Adalid-Peralta
Oct 4, 2015·Trends in Immunology·Antoine LouveauJonathan Kipnis
Feb 22, 2016·Micron : the International Research and Review Journal for Microscopy·Jana BulantováPetr Horák
Apr 23, 2016·Science·Mihai G NeteaRamnik J Xavier
Jun 22, 2017·Immunity·Robyn S Klein, Christopher A Hunter
Oct 12, 2018·Parasitology Research·Tomáš MacháčekLibor Mikeš
Dec 24, 2018·Parasite Immunology·Antonella CanoCraig W Roberts
Sep 27, 2019·Parasite Immunology·Rocío Alejandra Ruiz-ManzanoJorge Morales-Montor

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