PMID: 8583364Aug 1, 1995Paper

The peristaltic reflex in the rat ileum: evidence for functional mu- and delta-opiate receptors

The Journal of Pharmacy and Pharmacology
I M Coupar

Abstract

The potency order of opiate agonists at decreasing the rate of peristalsis in the rat isolated ileum was: difenoxin > loperamide > DADLE (D-Ala2-D-Leu5-enkephalin) > morphine > DSLET (D-Ser2,Leu5-Thr6-enkephalin). U-50488 (trans 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl) cyclohexyl) benzeneacetamide methane sulphonate) was inactive at 300 nM. Naloxone (400 nM) caused a significant 1.52-fold increase in the rate of peristaltic contractions and inhibited the effects of the active opiate agonists. The apparent pA2 values of naloxone were similar using difenoxin, loperamide and morphine as agonists, but the value was slightly, though significantly lower when DADLE was the agonist. It is suggested that the previously identified delta-opiate receptors of the rat small intestine have a functional role in suppressing the peristaltic reflex. The same response is subserved by mu-opiate receptors and either of these opiate-receptor subtypes could be activated by endogenous enkephalins.

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Citations

Jun 28, 2006·Cellular and Molecular Neurobiology·Walter J Lukiw
Jan 1, 1996·Pharmacology & Therapeutics·A De Luca, I M Coupar
Jun 23, 2011·Clinical and Experimental Gastroenterology·Glen S PattenMahinda Y Abeywardena
Nov 24, 2011·World Journal of Gastroenterology : WJG·Krishan KumarSantosh Pasha
Apr 1, 2017·Bulletin of Experimental Biology and Medicine·O Yu GrechkoV I Minkin
Aug 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Andrei SibaevMartin Storr
Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G J Sanger, B R Tuladhar
Jan 1, 1997·British Journal of Clinical Pharmacology·C H Wilder-Smith, A Bettiga
Jun 3, 2006·American Journal of Veterinary Research·Pedro BoscanJack R Snyder
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Martin StorrHans D Allescher

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