PMID: 557992May 2, 1977Paper

The permeability of aconitine-modified sodium channels to univalent cations in myelinated nerve

Biochimica Et Biophysica Acta
G N MozhayevaE D Nosyreva

Abstract

1. Ionic currents through the sodium system of nodes of Ranvier treated with aconitine were measured under voltage clamp conditions in a Ringer solution containing Na+ or an equimolar amount of various test cations. 2. Average shifts in reversal potentials in nodes of Ranvier treated with aconitine with NH4+, Li+, K+, Rb+, Cs+ in place of Na+ in the Ringer solution are 7.6, --6.8, --25.0, --41.0 and --51.5 mV at 13--14degrees C. At 20--22degrees C the sequence of shifts is 7.5, --5.5, --13.5, --29.0 and --41.0 mV. For Tl+ the the average reversal potential shift is +3 mV at 20--22degrees C. 3. The slope of the instantaneous current-voltage relation at the reversal potential in nodes treated with aconitine changed with the various cations tested. The ratios are NH4+/Na+/K+/Rb+/Cs+/Li+ = 1.14 : 1.0 : 0.80 :0.67 :0.53 : 0.53. 4. Using a three energy barrier model some of the parameters for the aconitine-modified Na+ channels were estimated (Chizmadgev, Yu. A., Khodorov, B.I. and Aityan, S.Kh. (1974) Bioelectrochem. Bioenerg. 1, 301--312).

References

Jul 6, 1973·Biochimica Et Biophysica Acta·P Läuger

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Citations

Aug 1, 1990·Pflügers Archiv : European journal of physiology·U LönnendonkerR Stämpfli
Jan 1, 1986·Pflügers Archiv : European journal of physiology·G N MozhayevaE D Nosyreva
Feb 1, 1983·Pflügers Archiv : European journal of physiology·G N Mozhayeva, A P Naumov
Feb 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·P Honerjäger, A Meissner
Oct 1, 1994·Pflügers Archiv : European journal of physiology·G M NicholsonT Narahashi
Jan 1, 1984·Neir̆ofiziologiia = Neurophysiology·G N MozhaevaE D Nosyreva
Jan 1, 1984·Neir̆ofiziologiia = Neurophysiology·G N MozhaevaB I Khodorov
Jan 1, 1986·Neir̆ofiziologiia = Neurophysiology·G N MozhaevaE D Nosyreva
Jan 1, 1982·Neir̆ofiziologiia = Neurophysiology·G N Mozhaeva, A P Naumov
Jan 1, 1982·Neir̆ofiziologiia = Neurophysiology·G N Mozhaeva, A P Naumov
Aug 1, 1996·Pflügers Archiv : European journal of physiology·H VaisP N Usherwood
Jan 1, 1985·Progress in Biophysics and Molecular Biology·B I Khodorov
Jan 1, 1990·General Pharmacology·P P NánásiD A Lathrop
Jun 1, 1982·Neuroscience·C Edwards
Nov 1, 1981·Journal of Ethnopharmacology·N G Bisset
Jan 23, 1990·European Journal of Pharmacology·M E Reith
Nov 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·G M NicholsonT Narahashi
May 1, 1981·The Journal of General Physiology·T Begenisich, D Busath
Jan 1, 1986·The Journal of General Physiology·J B Sutro
Jan 1, 1986·The Journal of General Physiology·M D LeibowitzB Hille
Mar 1, 1987·The Journal of General Physiology·S S Garber, C Miller
Mar 1, 1988·The Journal of General Physiology·S Barnes, B Hille
Jan 1, 1981·Progress in Biophysics and Molecular Biology·B I Khodorov
Jan 1, 1996·Neuropharmacology·A AmeriT Peters
Sep 5, 1984·Biochimica Et Biophysica Acta·G N MozhayevaE D Nosyreva
Jun 14, 1982·Biochimica Et Biophysica Acta·M Condrescu, R Villegas
Feb 6, 2004·Journal of Neurochemistry·Boris S Zhorov, Denis B Tikhonov
Apr 22, 1981·Biochimica Et Biophysica Acta·G N MozhayevaY A Negulyaev
Jan 1, 1980·Annals of the New York Academy of Sciences·M LazdunskiJ P Vincent
Dec 1, 1995·Bioscience Reports·H Vais, P N Usherwood

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