PMID: 5912206Jun 1, 1966

The permeability of the gastric mucosa of dog

The Journal of Physiology
M Altamirano, C Martinoya

Abstract

1. Tritiated water, [(14)C]urea, [(14)C]thiourea, [(14)C]sucrose and [(59)Fe]-haemoglobin were used to study the permeability of a semi-isolated piece of the great curvature of the canine stomach.2. The osmotic pressure of the solutions placed in contact with the secretory surface of the epithelium was changed by means of dextrose or urea. The mucosa behaved as a semi-permeable membrane, meaning that water flowed under gradients of osmotic pressure. Regardless of the solute used, about 45 x 10(-6) ml. of water flowed/cm(2)/min under a gradient of one atmosphere.3. The permeability constants of the probing molecules were determined under zero net volume flow obtained by placing isosmotic dextrose or isosmotic urea in the chamber. The constants decreased as the molecular volume of the probing molecules increased.4. The transport of all the non-electrolytes across the epithelium decreased significantly when the chamber contained isosmotic dextrose. Basically, this effect seems to be a result of the reduction of the area available for diffusion caused by the high molecular volume of dextrose.5. The increased hindrance to diffusion of the probing molecules caused by the added solutes is considered as good evidence that the probing m...Continue Reading

Citations

Jan 1, 1992·Annals of Biomedical Engineering·T ChandraD B Yeates
Oct 1, 1988·The Journal of Membrane Biology·C A Berry, A S Verkman
Dec 1, 1971·The Journal of Membrane Biology·A P Smulders, E M Wright
Jun 8, 1967·The New England Journal of Medicine·H W Davenport

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Thiourea

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