The peroxynitrite product 3-nitro-L-tyrosine attenuates the hemodynamic responses to angiotensin II in vivo

European Journal of Pharmacology
N W Kooy, S J Lewis

Abstract

Peroxynitrite is a potent oxidant formed endogenously by the near diffusion-limited reaction of nitric oxide with superoxide anion. Peroxynitrite specifically adds a nitro group to the ortho position of the phenolic ring of free and protein-associated tyrosines to form the stable product 3-nitro-L-tyrosine. Systemic administration of 3-nitro-L-tyrosine markedly inhibits the subsequent hemodynamic responses to alpha 1- and beta-adrenoceptor agonists in anesthetized rats. Angiotensin II is an important modulator of vascular tone. The vasoconstrictor effects of this hormone are known to involve the release of catecholamines from sympathetic tissues. In the present study, we examined whether 3-nitro-L-tyrosine (2.5 mumol/kg i.v.) would attenuate the hemodynamic responses produced by angiotensin II (0.1-1.0 microgram/kg i.v.). Angiotensin II produced increases in mean arterial pressure, and renal and mesenteric vascular resistances, but no changes in hindquarter vascular resistance. The pressor and renal and mesenteric vasoconstrictor responses produced by angiotensin II were significantly attenuated 30-60 min following the administration of 3-nitro-L-tyrosine. Further attenuation of these responses was evident 120-180 min following...Continue Reading

References

Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Nov 1, 1992·Archives of Biochemistry and Biophysics·J S BeckmanM Tsai
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Sep 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H OhshimaH Bartsch
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·N W KooyJ S Beckman
Feb 1, 1994·Free Radical Biology & Medicine·N W KooyJ S Beckman
Feb 1, 1994·Biological Chemistry Hoppe-Seyler·J S BeckmannC R White
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Sep 25, 1995·European Journal of Pharmacology·K Chen, B G Zimmerman

❮ Previous
Next ❯

Citations

Dec 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Trisha DasguptaDhananjay K Kaul
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Oct 19, 2004·The Journal of Clinical Investigation·Dhananjay K KaulMary E Fabry
Jul 4, 1996·European Journal of Pharmacology·N W Kooy, S J Lewis
May 26, 2004·The Journal of Nutritional Biochemistry·Ilaria PelusoMaura Palmery
Feb 25, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·M SchwemmerE Bassenge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

Archives of Biochemistry and Biophysics
H IschiropoulosJ S Beckman
Proceedings of the National Academy of Sciences of the United States of America
L M VillaS Moncada
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
H OhshimaH Bartsch
© 2021 Meta ULC. All rights reserved