The persistence of anticardiolipin antibodies is associated with an increased risk of the presence of lupus anticoagulant and anti-beta2-glycoprotein I antibodies

Rheumatology
C NevilleP R Fortin

Abstract

We studied antiphospholipid antibodies (aPL) in blood samples from a cohort of individuals followed for thrombosis to determine whether the persistent presence of anticardiolipin antibodies (aCL) is associated with a greater likelihood of having lupus anticoagulant and/or anti-beta2-glycoprotein I antibodies (LA/abeta2GPI). Blood samples from 353 individuals who had been tested for aCL on at least two occasions were tested for abeta2GPI and LA. Two groups were defined: aCL-persistent, who tested aCL-positive on at least two occasions, and aCL non-persistent, who tested aCL-positive on fewer than two occasions. Multivariate logistic regressions were performed using LA/abeta2GPI, LA and abeta2GPI as outcome variables and the percentage of aCL-positive tests as the predictor variable, adjusted for age, gender, family history of cardiovascular disease (CVD), systemic lupus erythematosus (SLE), smoking and number of venous (VT) and arterial thromboses (AT). Sixty-eight (19%) individuals were aCL persistent and 285 (81%) were aCL non-persistent. LA/abeta2GPI was found in 36 (53%) of the aCL persistent group and 38 (13%) of the aCL non-persistent group. The two groups were similar for age, gender and smoking. Family history of CVD, SL...Continue Reading

References

Mar 8, 2002·The New England Journal of Medicine·Jerrold S LevineJoyce Rauch
May 24, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Monica Galli, Tiziano Barbui
Jul 24, 2003·Thrombosis and Haemostasis·Carolyn NevillePaul R Fortin
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley

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Citations

Jul 6, 2016·Clinical Reviews in Allergy & Immunology·Steven R Binder, Christine M Litwin
Feb 12, 2019·Canadian Review of Sociology = Revue Canadienne De Sociologie·Christopher Greco
Aug 24, 2017·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Fehmi HindilerdenReyhan Diz-Kucukkaya
Dec 6, 2018·Clinical Rheumatology·María Del Carmen Zamora-MedinaJuanita Romero-Diaz

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