The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Annie M RacineAlzheimer's Disease Neuroimaging Initiative

Abstract

An Alzheimer's disease (AD) biomarker adjusted for age-related brain changes should improve specificity for AD-related pathological burden. We calculated a brain-age-adjusted "personalized AD cortical thickness index" (pADi) in mild cognitive impairment patients from the Alzheimer's Disease Neuroimaging Initiative. We performed receiver operating characteristic analysis for discrimination between patients with and without cerebrospinal fluid evidence of AD and logistic regression in an independent sample to determine if a dichotomized pADi predicted conversion to AD dementia. Receiver operating characteristic area under the curve was 0.69 and 0.72 in the two samples. Three empirical methods identified the same cut-point for pADi in the discovery sample. In the validation sample, 83% of pADi+ mild cognitive impairment patients were cerebrospinal fluid AD biomarker positive. pADi+ mild cognitive impairment patients (n = 63, 38%) were more likely to progress to AD dementia after 1 (odds ratio = 2.9) and 3 (odds ratio = 2.6) years. The pADi is a personalized, magnetic resonance imaging-derived AD biomarker that predicts progression to dementia.

References

Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y I ShelineM W Vannier
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Jul 20, 2004·BMJ : British Medical Journal·Jonathan J Deeks, Douglas G Altman
Jan 1, 1950·Cancer·W J YOUDEN
Sep 16, 2005·Biometrical Journal. Biometrische Zeitschrift·Ronen FlussBenjamin Reiser
Oct 29, 2005·Law and Human Behavior·Marnie E Rice, Grant T Harris
Jan 2, 2008·American Journal of Alzheimer's Disease and Other Dementias·G D RabinoviciH J Rosen
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Clifford R JackMichael W Weiner
Dec 26, 2008·Neurology·Akram BakkourBradford C Dickerson
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 20, 2009·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Kenneth J Drobatz
Jun 22, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Bradford C DickersonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 6, 2010·NeuroImage·Josephine BarnesNick C Fox
Apr 15, 2011·Neurology·B C DickersonL Detoledo-Morrell
Dec 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deepti PutchaReisa Sperling
Dec 23, 2011·Neurology·Bradford C DickersonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 7, 2012·Statistics in Medicine·Xinhua Liu
Oct 17, 2013·Frontiers in Aging Neuroscience·Bradford C DickersonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 24, 2013·Dementia & Neuropsychologia·Chiadi U OnyikePeter V Rabins
Feb 20, 2014·Progress in Neurobiology·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 5, 2015·Brain Imaging and Behavior·Edgar BusovacaAdam M Brickman
Jul 22, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackMichael Weiner
Mar 11, 2016·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici
Mar 26, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bruno DuboisUNKNOWN Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclin
Oct 30, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackRonald C Petersen
Feb 28, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Bradford C DickersonDavid A Wolk
Mar 10, 2017·Scientific Reports·Jong-Yun ParkUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 14, 2017·Neurobiology of Aging·Jean-Philippe CoutuUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Mar 21, 2017·JAMA Neurology·Stefanie SchreiberUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 6, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Lorna HarperJonathan M Schott

❮ Previous
Next ❯

Citations

Apr 8, 2020·Neuroinformatics·Yanshuai TuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 8, 2019·NeuroImage. Clinical·Chong-Yaw WeeUNKNOWN Alzheimers Disease Neuroimage Initiative
Nov 10, 2020·Medical Image Analysis·Gang WangUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 15, 2020·NeuroImage. Clinical·Rong YeStephen N Gomperts
Jul 27, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ramon CasanovaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 17, 2021·Brain Communications·McKenna E WilliamsWilliam S Kremen

❮ Previous
Next ❯

Software Mentioned

FreeSurfer

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Anders M FjellAlzheimer's Disease Neuroimaging Initiative
© 2022 Meta ULC. All rights reserved