The pertussis toxin liberation genes of Bordetella pertussis are transcriptionally linked to the pertussis toxin operon.

Infection and Immunity
S RicciV Scarlato

Abstract

The DNA sequence of the pertussis toxin operon (ptx) of Bordetella pertussis predicts that transcription of the operon ends downstream from the ptxS3 gene at a possible stem-loop structure. Secretion of the assembled pertussis toxin into the culture medium required the expression of 8 genes arranged in an operon (ptl) and lying 55 bp downstream from the ptx and ptl operons are cotranscribed and coregulated by the P(TOX) promoter. Deletion of the 55-bp DNA region caused an increase in the amount of the ptl transcripts. It is likely that this DNA region is involved in regulation of the ptx-pti expression.

References

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Citations

Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maria Laura BoschiroliDavid O'Callaghan
Dec 18, 2003·Journal of Bacteriology·Amy A Rambow-Larsen, Alison A Weiss

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