The Peter Pan paradigm

Theoretical Biology & Medical Modelling
J C Cohen, J E Larson

Abstract

Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis."You may delay, but time will not" Benjamin Franklin, USA Founding Father.

References

Feb 1, 1993·American Journal of Respiratory Cell and Molecular Biology·S A McGrathP L Zeitlin
Mar 1, 1995·Trends in Genetics : TIG·A J Copp
May 1, 1994·Journal of Pediatric Surgery·M H HedrickM R Harrison
Jan 1, 1997·British Medical Bulletin·C N Hales
Aug 15, 1998·Molecular Genetics and Metabolism·J C CohenJ E Larson
Nov 13, 1998·Current Opinion in Neurobiology·O Pourquié
Dec 16, 1998·Molecular Genetics and Metabolism·S L MorrowJ C Cohen
Aug 3, 1999·Biological Chemistry·H Büeler
Aug 5, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·J E LarsonJ C Cohen
Sep 26, 2000·Molecular Genetics and Metabolism·F Kaplan
Dec 22, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·J E LarsonJ C Cohen
Dec 26, 2001·American Journal of Respiratory Cell and Molecular Biology·Harmanjatinder S SekhonEliot R Spindel
Jan 26, 2002·Human Molecular Genetics·Fiona C Broackes-CarterAnn Harris
Aug 9, 2002·The New England Journal of Medicine·Joshua D GromanGarry R Cutting
Nov 15, 2002·Journal of Anatomy·Alison A Hislop
Dec 4, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Christina K HastonLap-Chee Tsui
Dec 6, 2002·The New England Journal of Medicine·Richard T L Couper
Jun 5, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Timothy A LyerlaRichard T Swank
Jun 6, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·A D R MackieF P Edenborough
Feb 7, 2004·Allergy·J BousquetM Humbert
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Laurent VergnesKaren Reue
Nov 25, 2004·Clinics in Liver Disease·K D Flora, K G Benner
Dec 23, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kimberly A MooreDonald E Ingber
Feb 9, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Amanda L BrennanEmma H Baker
Feb 15, 2005·Placenta·E Jauniaux, G J Burton
Mar 26, 2005·American Journal of Respiratory Cell and Molecular Biology·Susan H GuttentagSandra R Bates
May 14, 2005·American Journal of Respiratory Cell and Molecular Biology·Neil C FeatherstoneTheodor V Burdyga
May 26, 2005·American Journal of Physiology. Renal Physiology·Nikki L Jernigan, Heather A Drummond
Jul 9, 2005·Journal of Biochemistry·Yan Yin, Liang Ma
Aug 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Donald E Ingber
Aug 23, 2005·Proceedings of the American Thoracic Society·Luis J V GaliettaOlga Zegarra-Moran
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Garry R Cutting
Sep 15, 2005·Wiener klinische Wochenschrift·Miroslav Mikulecký, Iveta Cierna
Nov 17, 2005·Journal of Cellular Biochemistry·Carrie A AdelmanClaire L Attwooll
Jan 28, 2006·Biochimica Et Biophysica Acta·Susanne HeimerlGerd Schmitz
Feb 14, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Janet E Larson, J Craig Cohen
Mar 7, 2006·European Journal of Epidemiology·Vincent W V Jaddoe, Jacqueline C M Witteman
Apr 4, 2006·Journal of Animal Science·J M ReecyC H Stahl
Apr 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·E C JesudasonP D Losty
Apr 14, 2006·Hormone Research·D B DungerK K Ong

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Citations

Apr 23, 2009·JAMA : the Journal of the American Medical Association·S V SubramanianNeetu A John
Apr 15, 2014·Integrative and Comparative Biology·H Frederik Nijhout, Michael C Reed
Feb 20, 2009·Journal of Bioinformatics and Computational Biology·Ao YuanCharles Rotimi
May 5, 2018·Frontiers in Physiology·Mario CeresaMiguel A González Ballester

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