PMID: 32404Dec 1, 1978

The pH of prostatic fluid: a reappraisal and therapeutic implications

The Journal of Urology
W R Fair, J J Cordonnier


A basic assumption in all experiments on prostatic physiology, particularly those designed to study the diffusion of drugs into the prostate gland, is that the pH of human prostatic fluid is similar to that of the dog, that is pH 6.1 to 6.5. We believe that this assumption is incorrect. Our data indicate 1) the expressed prostatic secretion of most normal men is alkaline (mean pH 7.31), 2) with prostatic infection the pH of prostatic fluid increases markedly (mean pH 8.34) and, therefore, drugs shown to diffuse into the canine prostate may be ineffective in treating prostatitis in humans and 3) the increase in pH of the expressed prostatic secretion seen with infection is not simply owing to an increase in the relative concentration of alkaline seminal vesicular components. Biochemical markers of seminal vesicular activity (fructose and prostaglandins) showed no correlation with pH values of expressed prostatic secretion. Hence, it appears that the change in pH of the expressed secretion is owing to a real increase in pH of prostatic fluid. The clinical implications of these findings are discussed. An appreciation of the profound variation in the prostatic fluid pH may be of importance not only in furthering the understanding a...Continue Reading


Jul 13, 1968·Nature·D G WinninghamT A Stamey
Feb 1, 1973·The Journal of Clinical Investigation·B M JaffeC W Parker
Feb 1, 1970·The Journal of Urology·T A StameyD G Winningham


Jan 1, 1991·International Urology and Nephrology·I Romics, D Bach
Jan 1, 1985·The Prostate·P C Frimodt-MøllerP O Madsen
Jan 1, 1983·The Prostate·K M Jensen, P O Madsen
Jun 13, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·T GotoH Hayami
May 23, 2001·Biology of Reproduction·C M Herak-KrambergerI Sabolic
Feb 6, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Iwona Ostaszewska-PuchalskaZofia Galewska
Mar 18, 2011·British Journal of Pharmacology·S VenturaB Exintaris
Dec 18, 2013·Investigative Radiology·Miriam W LagemaatTom W J Scheenen
Oct 1, 1988·The Journal of Urology·L Baert, A Leonard
Feb 1, 1995·The Journal of Urology·J C NickelM Olson
Mar 29, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Miriam W LagemaatTom W J Scheenen
Apr 5, 2013·Clinical Microbiology Reviews·Daniel GonzalezHartmut Derendorf
Jan 18, 2015·The Journal of Urology·Robert R Bahnson
Jan 1, 1984·Urological Research·P C Frimodt-MøllerP O Madsen
Jan 1, 1982·The Prostate·K M JensenP O Madsen
Oct 1, 1982·International Journal of Andrology·J P KavanaghC B Costello
Dec 22, 2004·Current Infectious Disease Reports·F M E Wagenlehner, K G Naber
Jul 29, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Bozena Zdrodowska-StefanowZofia Galewska
Apr 1, 1979·The Journal of Urology·W R FairW D Heston
Jan 1, 1983·Urological Research·P O MadsenP Iversen
Jan 1, 1991·Infection·P O Madsen, J Aagaard
Feb 1, 1980·The Journal of Urology·E M Meares
Dec 1, 1984·European Journal of Clinical Microbiology·M Barza, G Cuchural
Dec 11, 1987·Pharmaceutisch Weekblad. Scientific Edition·T N LangemeyerT van der Wal
Sep 29, 1998·The Journal of Urology·P M Joseph
Jan 1, 1996·International Urology and Nephrology·V Y ZaichickS V Zaichick
Mar 10, 2001·Journal of Chemotherapy·S ScelziM Rizzo

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