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The pH shift and precursor feeding strategy in a low-toxicity FR-008/candicidin derivative CS103 fermentation bioprocess by a mutant of Streptomyces sp. FR-008

Applied Biochemistry and Biotechnology

Dec 1, 2009

Xiangzhao MaoDong-Zhi Wei

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Abstract

CS103, the novel derivative of polyene macrolides antibiotic FR-008/candicidin with lower toxicity has been isolated from the culture mycelia of the mutant of Streptomyces sp. FR-008, with targeted deletions of the fscP cytochrome P450 gene from its chromosome. To enhance biosynthesis o...read more

Mentioned in this Paper

Antibiotics
Macrolide Antibiotics
Bioformation
Candicidin
Chromosomes
Cytochrome P450
Fermentation
Hydrogen-Ion Concentration
Polyenes
Streptomyces
Paper Details
References
  • References9
  • Citations4
1

The pH shift and precursor feeding strategy in a low-toxicity FR-008/candicidin derivative CS103 fermentation bioprocess by a mutant of Streptomyces sp. FR-008

Applied Biochemistry and Biotechnology

Dec 1, 2009

Xiangzhao MaoDong-Zhi Wei

PMID: 19148776

DOI: 10.1007/s12010-008-8502-y

Abstract

CS103, the novel derivative of polyene macrolides antibiotic FR-008/candicidin with lower toxicity has been isolated from the culture mycelia of the mutant of Streptomyces sp. FR-008, with targeted deletions of the fscP cytochrome P450 gene from its chromosome. To enhance biosynthesis o...read more

Mentioned in this Paper

Antibiotics
Macrolide Antibiotics
Bioformation
Candicidin
Chromosomes

Related Papers

Paper Details
References
  • References9
  • Citations4
1

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