journal cover

The pH shift and precursor feeding strategy in a low-toxicity FR-008/candicidin derivative CS103 fermentation bioprocess by a mutant of Streptomyces sp. FR-008

Applied Biochemistry and Biotechnology

Jan 17, 2009

Xiangzhao MaoDongzhi Wei

Abstract

CS103, the novel derivative of polyene macrolides antibiotic FR-008/candicidin with lower toxicity has been isolated from the culture mycelia of the mutant of Streptomyces sp. FR-008, with targeted deletions of the fscP cytochrome P450 gene from its chromosome. To enhance biosynthesis o...read more

Mentioned in this Paper

Macrolide Antibiotics
Cytochrome P450
Polyenes
Macrolides
Vanobid
Cytochrome P450 Activity
Chromosomes
Mutant
Fermentation
Candicidin
Paper Details
References
  • References9
  • Citations4
1

The pH shift and precursor feeding strategy in a low-toxicity FR-008/candicidin derivative CS103 fermentation bioprocess by a mutant of Streptomyces sp. FR-008

Applied Biochemistry and Biotechnology

Jan 17, 2009

Xiangzhao MaoDongzhi Wei

PMID: 19148776

DOI: 10.1007/s12010-008-8502-y

Abstract

CS103, the novel derivative of polyene macrolides antibiotic FR-008/candicidin with lower toxicity has been isolated from the culture mycelia of the mutant of Streptomyces sp. FR-008, with targeted deletions of the fscP cytochrome P450 gene from its chromosome. To enhance biosynthesis o...read more

Mentioned in this Paper

Macrolide Antibiotics
Cytochrome P450
Polyenes
Macrolides
Vanobid
Cytochrome P450 Activity
Chromosomes
Mutant
Fermentation
Candicidin

Related Papers

Paper Details
References
  • References9
  • Citations4
1
/papers/the-ph-shift-and-precursor-feeding-strategy-in-a/19148776