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The pH variation of steady-state kinetic parameters of site-specific Co(2+)-reconstituted liver alcohol dehydrogenase. A mechanistic probe for the assignment of metal-linked ionizations

The Journal of Biological Chemistry

Nov 5, 1991

W Maret, M W Makinen

PMID: 1939113

Abstract

To identify ionizations of the active site metal-bound water in horse liver alcohol dehydrogenase (alcohol:NAD+ oxidoreductase; EC 1.1.1.1), the pH, solvent isotope, temperature, and anion dependences of the steady-state kinetic parameters kcat and kcat/KM have been evaluated under init...read more

Mentioned in this Paper

Thermodynamics
Ethanol
Benzyl Alcohol
Cyclohexanol
Ions
HSD17B6
Oxidation
Zinc
Alcohol Dehydrogenase II
1-Propanol
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The pH variation of steady-state kinetic parameters of site-specific Co(2+)-reconstituted liver alcohol dehydrogenase. A mechanistic probe for the assignment of metal-linked ionizations

The Journal of Biological Chemistry

Nov 5, 1991

W Maret, M W Makinen

PMID: 1939113

DOI:

Abstract

To identify ionizations of the active site metal-bound water in horse liver alcohol dehydrogenase (alcohol:NAD+ oxidoreductase; EC 1.1.1.1), the pH, solvent isotope, temperature, and anion dependences of the steady-state kinetic parameters kcat and kcat/KM have been evaluated under init...read more

Mentioned in this Paper

Thermodynamics
Ethanol
Benzyl Alcohol
Cyclohexanol
Ions
HSD17B6
Oxidation
Zinc
Alcohol Dehydrogenase II
1-Propanol

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