The pharmaceutical multi-activity of metallofullerenol invigorates cancer therapy

Nanoscale
Jinxia LiYuliang Zhao

Abstract

Currently, cancer continues to afflict humanity. The direct destruction and killing of tumor cells by surgery, radiation and chemotherapy gives rise to many side effects and compromised efficacy. Encouragingly, the rapid development of nanotechnology offers attractive opportunities to revolutionize the current situation of cancer therapy. Metallofullerenol Gd@C82(OH)22, in contrast to chemotherapeutics that directly kill tumor cells, demonstrates anti-tumor behavior with high efficiency and low toxicity by modulating the tumor microenvironment. Furthermore, Gd@C82(OH)22 has been recently reported to specifically target cancer stem cells. In this review, we give a concise introduction to the development of the fullerene family and then report the anti-tumor activity of Gd@C82(OH)22 based on its unique physicochemical characteristics, followed by a comprehensive summary of the anti-tumor biological mechanisms which target different components of the tumor microenvironment as well as the biodistribution and toxicity of Gd@C82(OH)22. Finally, we describe Gd@C82(OH)22 as a "particulate medicine" to highlight its distinctions from conventional "molecular medicine", with considerable emphasis on the advantages of nanomedicine. The in-...Continue Reading

References

Jan 1, 1990·Free Radical Research Communications·R H BurdonC Rice-Evans
May 1, 1989·Environmental Health Perspectives·B D GoldsteinG Witz
Jan 1, 1987·Journal of Cell Science. Supplement·M J Bissell, M H Barcellos-Hoff
Nov 7, 1982·Journal of Theoretical Biology·M J BissellG Parry
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·D W CagleL J Wilson
Oct 18, 2000·Critical Reviews in Oncology/hematology·B Desoize, J Jardillier
Jan 9, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J C Kaplan, C Junien
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Apr 27, 2001·Seminars in Cancer Biology·W G Stetler-Stevenson, A E Yu
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Michael Papetti, Ira M Herman
May 25, 2002·Seminars in Cancer Biology·Isaac P Witz
Jan 17, 2003·Clinical Medicine : Journal of the Royal College of Physicians of London·Karol Sikora
Mar 5, 2003·Trends in Molecular Medicine·Marya F McCartyLee M Ellis
Mar 20, 2003·British Journal of Cancer·P RicchiA M Acquaviva
Jun 18, 2003·Trends in Immunology·Francesco M MarincolaSoldano Ferrone
Aug 22, 2003·Nature·Kenneth M Yamada
May 12, 2004·Nature Reviews. Drug Discovery·Napoleone FerraraWilliam Novotny
May 26, 2004·Critical Reviews in Oncology/hematology·G KleinE S J M de Bont
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Sep 1, 2004·Cancer Immunology, Immunotherapy : CII·Karl-Johan Malmberg
Jan 28, 2005·Angewandte Chemie·Matthias Krause, Lothar Dunsch
Feb 3, 2005·Nature Reviews. Drug Discovery·Curtis T KeithBrent R Stockwell
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Mar 16, 2005·Current Opinion in Immunology·Willem W Overwijk
Dec 22, 2005·Nature Reviews. Genetics·Andrew P FeinbergSteven Henikoff
Jan 18, 2006·Annual Review of Medicine·Judah Folkman
Feb 17, 2006·Investigative Radiology·Stasia A AndersonJoseph A Frank
Feb 24, 2006·Nature Reviews. Cancer·Cornelia M UlrichJohn D Potter
Jul 21, 2006·The Journal of Physical Chemistry. B·Jun TangRun Su
Oct 13, 2006·Current Opinion in Gastroenterology·R N Dubois
Dec 13, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jian LiuYasuhiko Tabata
Aug 2, 2007·Journal of Cellular Biochemistry·Bharat B AggarwalShishir Shishodia
Oct 25, 2007·Nature Reviews. Cancer·Julio A Aguirre-Ghiso
Jan 29, 2008·Recent Patents on Anti-cancer Drug Discovery·Ferdinando Mannello
Jan 30, 2008·CA: a Cancer Journal for Clinicians·Xu WangDong M Shin

❮ Previous
Next ❯

Citations

Feb 16, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Haijun MaChunru Wang
Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haonan LiKui Luo
Jun 5, 2021·Life Sciences·Bruna Stefane Alves de OliveiraHafiz M N Iqbal

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic light scattering
electron spin resonance
chemical

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.