PMID: 8968661Dec 1, 1996Paper

The pharmacodynamic effects of an oral contraceptive containing 3 mg micronized 17 beta-estradiol and 0.150 mg desogestrel for 21 days, followed by 0.030 mg desogestrel only for 7 days

Contraception
G CsemiczkyB M Landgren

Abstract

During oral treatment with 3 mg micronized 17 beta-estradiol and 0.150 mg desogestrel for 21 days followed by 0.030 mg (A) desogestrel (15 women) or placebo (B) (14 women) for 7 days, ovarian function, bleeding pattern and estradiol levels were evaluated. The study was performed in a group-comparative, double-blind fashion. During a pre-treatment control cycle, using ultrasound scan, follicular diameter was measured on cycle days 10-16 and endometrial thickness on one of cycle days 22-26. Estradiol was measured at the time of ultrasound scan and progesterone three times in the luteal phase. During three treatment cycles, follicular diameter and endometrial thickness were monitored three times weekly and at the same time, estradiol and progesterone were measured. Treatment resulted in anovulation in all women. Maximum and mean estradiol levels were approximately 900 pmol/l and 550 pmol/l during treatment, respectively, and approximately 200 pmol/l during the estradiol-free weeks in both groups. Ten women showed ovarian activity (follicle size > or = 15 mm) during treatment, seven in group A and three in group B. Endometrial thickness decreased approximately 3 mm during treatment in both groups. The incidence of breakthrough blee...Continue Reading

References

Sep 1, 1979·British Journal of Obstetrics and Gynaecology·B AstedtL Svanberg
Sep 1, 1985·Endocrinology·J M Larner, R B Hochberg
Dec 1, 1985·Journal of Steroid Biochemistry·C LongcopeJ Warram
Apr 1, 1974·The Journal of Clinical Endocrinology and Metabolism·C Longcope, K I Williams
May 1, 1980·Acta Endocrinologica·B M LandgrenE Diczfalusy
Dec 1, 1982·Contraception·E WangE Diczfalusy

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Citations

Dec 15, 2012·Advances in Therapy·Elizabeth A Micks, Jeffrey T Jensen
Dec 9, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Santiago PalaciosJohannes Bitzer
Oct 23, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H HoffmannM Oettel
Sep 6, 2011·International Journal of Women's Health·Jessica W Kiley, Lee P Shulman
Dec 17, 2009·Contraception·Franca Fruzzetti, Johannes Bitzer
Feb 9, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Joaquim Calaf I Alsina
Feb 22, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Nathalie Chabbert-BuffetSophie Christin-Maitre
Jul 1, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Susan ZeunHartmut Blode
Sep 29, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Ulla M ÅgrenEllen Mommers
Apr 4, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Franca FruzzettiJohannes Bitzer
Aug 13, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nathalie Chabbert-BuffetAxelle Pintiaux
Apr 7, 2010·Expert Opinion on Pharmacotherapy·Jeffrey T Jensen
Oct 17, 2018·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano

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