The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.

Clinical Pharmacology and Therapeutics
Deanna L KroetzKathleen M Giacomini

Abstract

Since the cloning of the first membrane transporter, our understanding of the role of transporters in clinical drug disposition and response has grown enormously. In parallel, large-scale genome-wide variation studies and the emerging field of pharmacogenomics have ushered in a new understanding of variations in drug response. At the crossroads of pharmacogenomics and transporter biology is the National Institutes of Health-funded Pharmacogenomics of Membrane Transporters (PMT) project, centered at the University of California, San Francisco.

References

Jul 27, 2002·Pharmacogenetics·Maya K LeabmanUNKNOWN Pharmacogenetics of Membrane Transporters Investigators
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Maya K LeabmanUNKNOWN Pharmacogenetics Of Membrane Transporters Investigators
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yan ShuUNKNOWN Pharmacogenetics Of Membrane Transporters Investigators
Feb 24, 2004·Molecular Pharmacology·Jennifer H GrayKathleen M Giacomini
Jul 30, 2004·The Journal of Pharmacology and Experimental Therapeutics·Julia PinsonneaultWolfgang Sadée
May 3, 2005·Pharmacogenetics and Genomics·Tomoe FujitaKathleen M Giacomini
Oct 11, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ryan P OwenKathleen M Giacomini
Nov 1, 2005·The Journal of Pharmacology and Experimental Therapeutics·Pascale AnderleWolfgang Sadée
Nov 18, 2005·American Journal of Physiology. Renal Physiology·Andrew R ErdmanKathleen M Giacomini
Dec 16, 2005·Genome Research·Thomas J UrbanKathleen M Giacomini
May 17, 2006·The Journal of Pharmacology and Experimental Therapeutics·Ilaria BadagnaniKathleen M Giacomini
Aug 26, 2006·Molecular Pharmacology·Thomas J UrbanKathleen M Giacomini
Dec 23, 2006·Clinical Pharmacology and Therapeutics·F A de JongA Sparreboom
May 4, 2007·The Journal of Clinical Investigation·Yan ShuKathleen M Giacomini
Jul 5, 2007·Clinical Pharmacology and Therapeutics·Y ShuK M Giacomini
Aug 19, 2007·Pharmacogenetics and Genomics·Thomas J UrbanKathleen M Giacomini
Feb 22, 2008·The Journal of Pharmacology and Experimental Therapeutics·Jason M GowDeanna L Kroetz
Mar 28, 2008·The Journal of Pharmacology and Experimental Therapeutics·Nada AblaDeanna L Kroetz
Dec 23, 2008·The Journal of Pharmacology and Experimental Therapeutics·Sook Wah YeeKathleen M Giacomini
Jan 15, 2009·The Journal of Pharmacology and Experimental Therapeutics·Harunobu TaharaKathleen M Giacomini
Jan 28, 2009·The Pharmacogenomics Journal·Ying ChenKathleen M Giacomini
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico InnocentiMark J Ratain
Jun 2, 2009·Pharmacogenetics and Genomics·Ying ChenKathleen M Giacomini

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Citations

Nov 19, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stuart A Scott
Mar 31, 2010·Pharmacogenomics·Sook Wah YeeKathleen M Giacomini
May 31, 2011·Pharmacogenomics·Bruno Stieger, Peter J Meier
Sep 21, 2013·Annual Review of Pharmacology and Toxicology·Susan P C Cole
Apr 4, 2015·Expert Opinion on Drug Metabolism & Toxicology·Frank J GonzalezXiaochao Ma
Aug 23, 2012·Journal of Pharmaceutical Sciences·Malcolm RowlandVinod P Shah
Feb 11, 2011·Human Mutation·Sarah C SimMagnus Ingelman-Sundberg
Jan 31, 2013·Clinical Journal of Oncology Nursing·Ellen M Lavoie Smith
Jul 8, 2016·Journal of Clinical Pharmacology·Ying FanLei Zhang
Sep 11, 2010·Forensic Science International : Synergy·Frank MusshoffBurkhard Madea
Jun 24, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David E SmithRichard F Keep
Nov 23, 2011·Biomarkers in Medicine·Scott A Waldman, Andre Terzic
Oct 15, 2011·American Journal of Physiology. Cell Physiology·Pedro Cano-SoldadoMarçal Pastor-Anglada
Feb 23, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rachel J EclovDeanna L Kroetz
Oct 2, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gwenaëlle Conseil, Susan P C Cole
Sep 21, 2017·Pharmacogenetics and Genomics·Rachel J EclovDeanna L Kroetz
Nov 10, 2016·Drug Metabolism and Personalized Therapy·Brendon PearceMongi Benjeddou
Sep 16, 2020·International Journal of Molecular Sciences·Zulfan ZazuliRosalinde Masereeuw
Mar 23, 2011·Clinical Pharmacology and Therapeutics·C S Lancaster, A Sparreboom
Jun 28, 2019·Frontiers in Pharmacology·Gopal PawarMark T D Cronin

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