PMID: 43233Nov 1, 1979

The pharmacokinetic profile of ochratoxin A in the rat after oral and intravenous administration

Drug Metabolism and Disposition : the Biological Fate of Chemicals
P GaltierC Labouche


A single oral or iv dose (2.5 mg/kg) of ochratoxin A was administered to healthy adult rats. A spectrofluorimetric method was used to determine the toxin level in plasma. The results suggest that the toxin is distributed in two kinetically distinct body compartments. By use of computer techniques, values were assigned to the pharmacokinetic parameters for ochratoxin A in the rat. The half-life of the drug was around 55 hr for either oral or iv administration. Digital computer-simulated curves of the toxin levels in the central and peripheral compartments as well as a total elimination curve were generated. When 14C-ochratoxin A was administered to rats, there were peaks of radioactivity 1 and 6 hr after injection. Ochratoxin alpha was the only metabolite recovered from the cecum and large intestine. Ochratoxin A was excreted via urine and feces, both as the free drug and hydroylzed to ochratoxin alpha; in urine there were five unidentified labeled metabolites. Some of the water-soluble radioactivity was not recovered in the acidic ether extract of the excreta. A hierarchical clustering technique was used to classify the organs in central and peripheral compartments. Muscle, fat, and skin were found to belong to the deep compart...Continue Reading

Related Concepts

Intravenous Injections
Drug or Chemical Tissue Distribution

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
P GaltierM Alvinerie
The Journal of Pharmacology and Experimental Therapeutics
P A WyssM H Bickel
Toxicology and Applied Pharmacology
J G PaceR W Wannemacher
Drug Metabolism and Disposition : the Biological Fate of Chemicals
M J McNultyJ W Findlay
© 2020 Meta ULC. All rights reserved