PMID: 3761558Jun 1, 1986

The pharmacokinetic studies on astromicin in dogs. Intramuscular, intravenous or drip intravenous administration

The Japanese journal of antibiotics
S KobayashiT Deguchi

Abstract

The pharmacokinetics of astromicin (ASTM), a new aminoglycoside antibiotics, was studied in dogs after intramuscular (i.m.), intravenous (i.v.) or drip intravenous (d.i.v.: for 0.5, 1 hr. or 2 hrs.) administration at a dose of 20 mg/kg. The pharmacokinetic parameters were calculated using one-compartment open model (i.m.) or two-compartment open model (i.v. and d.i.v.). The peak plasma levels of ASTM were 34.1 mcg/ml (i.m.), 50.5 mcg/ml (d.i.v., 0.5 hr.), 39.8 mcg/ml (d.i.v., 1 hr.) and 28.2 mcg/ml (d.i.v., 2 hrs.), respectively. The pharmacokinetic parameters (T1/2, AUC infinity, Kel, Vd and Cl) of ASTM except Cmax and Tmax were similar for different routes of administration. Urinary recovery rates of ASTM were 90.5% (i.m.), 95.2% (i.v.), 91.6% (d.i.v., 0.5 hr.), 92.6% (d.i.v., 1 hr.) and 93.5% (d.i.v., 2 hrs.) by 24 hours. After intramuscular, intravenous or 1 hour drip intravenous administration of ASTM, no active metabolite was found in urine of dogs.

Related Concepts

Fortimicin A sulfate (1: 2)
Aminoglycosides
Metazoa
Bacteriocidal Agents
Canis familiaris
Intravenous Infusion Procedures
Intramuscular Injection
Intravenous Injections
Antibiotics, Aminoglycoside
Canis familiaris

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Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.