The pharmacokinetics and safety of porfimer after repeated administration 30-45 days apart to patients undergoing photodynamic therapy.

Alimentary Pharmacology & Therapeutics
S P PereiraJ Spénard

Abstract

Porfimer is an intravenous (i.v.) injectable photosensitizing agent used in the photodynamic treatment of tumours and of high-grade dysplasia in Barrett's oesophagus. To assess the pharmacokinetics as well as the safety profiles of porfimer after a first and a second dose administered 30-45 days apart in patients undergoing photodynamic therapy. Nineteen patients (16 with cholangiocarcinoma) were enrolled. Porfimer sodium was administered by i.v. injection over 3-5 min. Blood samples were collected prior to starting i.v. drug injection and postdose at different time points after the first and second administrations. Porfimer exposure values after the second administration were statistically higher than those observed after the first administration, suggesting a slight accumulation of porfimer following repeated administration. The apparent mean elimination half-life of porfimer increased from 410 h after the first administration to 725 h after the second administration. The safety profiles of porfimer after a first and a second administration were similar and did not raise additional concern. Eight patients experienced nine serious adverse events. Only photosensitivity was deemed study-drug related. Porfimer appears to display ...Continue Reading

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Citations

Jun 5, 2013·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Mariette BengtssonBodil Ohlsson
Sep 4, 2014·Current Gastroenterology Reports·Kamran QureshiAbdullah M S Al-Osaimi
Nov 8, 2011·Lasers in Surgery and Medicine·Maria-Anna Ortner
Feb 21, 2013·Clinical Endoscopy·Bashar J QumseyaHerbert C Wolfsen
Jan 17, 2021·Photodiagnosis and Photodynamic Therapy·Ivan S Mfouo-TyngaCristina Kurachi

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