The pharmacokinetics of 2,2',5,5'-tetrachlorobiphenyl and 3,3',4,4'-tetrachlorobiphenyl and its relationship to toxicity

Toxicology and Applied Pharmacology
M A ClevengerR C James

Abstract

The pharmacokinetics of two toxicologically diverse tetrachlorobiphenyls (TCBs) were measured in mice. After dosing to apparent steady-state conditions, 2,2',5,5'-TCB was found to have a tissue elimination half-life of between 1.64 and 2.90 days. The half-life of 3,3',4,4'-TCB was similar, ranging from 1.07 to 2.60 days. Systemic clearance and volume of distribution estimates were also similar for the two TCB isomers. The 3,3',4,4'-isomer had a substantially greater partitioning from serum into adipose, liver, and thymic tissues. With dosing regimens developed using these measured pharmacokinetic parameters, experiments were undertaken to compare toxic potency of these two TCBs when similar tissue concentrations of the two isomers were achieved in target and storage tissues. These studies demonstrated that thymic atrophy occurs at lower 3,3',4,4'-TCB doses and tissue concentrations than those required to produce hepatotoxicity. These two organ toxicities were produced only by 3,3',4,4'-TCB despite the fact that equivalent or higher tissue concentrations of 2,2',5,5'-TCB were achieved in vivo in all tissues. We conclude that the in vivo difference in the toxic potency of these two TCB isomers does not result from the significant...Continue Reading

References

May 31, 1979·Annals of the New York Academy of Sciences·H YoshimuraM Miki
Oct 1, 1977·Bulletin of Environmental Contamination and Toxicology·T MizutaniM Matsumoto
Sep 1, 1975·Journal of Agricultural and Food Chemistry·S SafeD Jones
Dec 19, 1973·Biochemical and Biophysical Research Communications·A M GardnerE P Ragelis
Jan 1, 1972·Journal of the Chemical Society. Perkin Transactions 1·S Safe, O Hutzinger
Jul 1, 1972·Bulletin of Environmental Contamination and Toxicology·P W Albro, L Fishbein
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·H B Matthews, R L Dedrick
May 1, 1980·Toxicology and Applied Pharmacology·S KatoH B Matthews
May 1, 1981·Toxicology and Applied Pharmacology·M BioccaJ A Moore
Jul 1, 1982·Canadian Journal of Physiology and Pharmacology·S SafeM A Campbell
Apr 1, 1982·Journal of Pharmaceutical Sciences·D Perrier, M Gibaldi

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Citations

Aug 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·K Nesaretnam, P Darbre
Dec 1, 1992·Ecotoxicology and Environmental Safety·M H Li, M J McKee

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