The pharmacokinetics of a single dose of artemisinin in patients with uncomplicated falciparum malaria.

The American Journal of Tropical Medicine and Hygiene
P J de VriesP A Kager

Abstract

The pharmacokinetics of artemisinin was studied in 11 Vietnamese patients with uncomplicated falciparum malaria after a single 500 mg oral dose. Curative treatment with mefloquine (15 mg/kg) was provided 24 hr after the artemisinin dose. Artemisinin concentrations were measured by high-performance liquid chromatography with electrochemical detection. The following pharmacokinetic results were found (all mean +/- SD); calculated volume of distribution/bioavailability = 22.8 +/- 16.6 L.kg-1, mean absorption time = 1.16 +/- 0.92 hr, calculated maximum concentration = 364 +/- 250 micrograms.L-1 occurring at 2.88 +/- 1.71 hr after drug intake, and an elimination half-life of 2.72 +/- 1.76 hr. Bioavailability was low. These results do not differ from results in healthy subjects. Parasites disappeared rapidly, with a mean parasite clearance time of 36 hr. No relationship was found between pharmacokinetics and the parasite elimination rate. Tolerance to the single dose of artemisinin was good. No adverse effects were detected. In conclusion, pharmacokinetics of a single dose of artemisinin for uncomplicated falciparum malaria is not different from findings in healthy subjects. A single dose of 500 mg of artemisinin is effective in redu...Continue Reading

Citations

May 17, 2001·Antimicrobial Agents and Chemotherapy·A MorenoP Druilhe
Mar 21, 2007·Basic & Clinical Pharmacology & Toxicology·Guofen QiaoBaiyan Li
Nov 4, 2000·Expert Opinion on Investigational Drugs·R N Price
Dec 16, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·R KoopmansC J van Boxtel
May 4, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiao-mei GongShen Fu
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Nehal VyasChristy M Wyandt
Jul 4, 2001·Clinical Pharmacokinetics·P T Giao, P J de Vries
Apr 6, 2021·Frontiers in Pharmacology·Fatih M UckunVuong Trieu
Feb 9, 2000·Life Sciences·V DhingraM Lakshmi Narasu

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