The pharmacokinetics of a single rectal dose of paracetamol (40 mg x kg(-1)) in children with liver disease

Paediatric Anaesthesia
C R H CormackTanya Howell

Abstract

The aim of our study was to measure the serum paracetamol concentrations achieved following a single rectal loading dose of 40 mg x kg(-1) in children with chronic liver disease. We recruited 17 children (3-15 years, 10.6-75 kg) undergoing minor surgical procedures under general anesthesia. Paracetamol was administered at the end of surgery and blood samples were taken for analysis at 2, 3, 4, 6 and 8 h postdose. The mean Cmax of 11.4 mg x l(-1) [coefficient of variation (CV) 66%] was achieved at a Tmax of 2.7 h (CV 42%). The relative bioavailability (F) of the suppository formulation was not estimated, but clearance (Cl/F) estimates 0.73 l x kg(-1) x h(-1) (CV 87%) and time-concentration profiles for these children were similar to the normal pediatric population. There are currently no biologic markers available for monitoring possible hepatotoxicity in this cohort of patients with liver disease, but our data suggest that a single-dose suppository is a satisfactory analgesic alternative.

References

Jul 1, 1979·European Journal of Clinical Pharmacology·J A ForrestL F Prescott
Aug 1, 1991·British Journal of Clinical Pharmacology·A Penna, N Buchanan
Jul 1, 1989·Clinical Pharmacology and Therapeutics·P D WalsonL Alexander
May 1, 1986·Clinical Pharmacokinetics·C Jorup-RönströmS Britton
Dec 1, 1985·Drug Intelligence & Clinical Pharmacy·B H Rumack
Jan 1, 1995·Paediatric Anaesthesia·B J AndersonN H Holford
Jan 1, 1994·Journal of Toxicology. Clinical Toxicology·G R BondC Taylor
Nov 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C J MontgomeryC P Marsland
Jan 1, 1996·European Journal of Clinical Pharmacology·S S al-ObaidyP S Collier
Dec 1, 1996·Anaesthesia and Intensive Care·B AndersonG Woollard
Apr 17, 1999·Journal of Pharmacokinetics and Biopharmaceutics·R D BrownJ T Wilson
Jul 21, 1999·European Journal of Drug Metabolism and Pharmacokinetics·A Esteban, M Pérez-Mateo
Sep 15, 1999·The Journal of Pediatrics·B J AndersonR Aicken
Mar 31, 2000·Clinical Pharmacology and Therapeutics·P T ManyikeJ T Slattery
Nov 7, 2000·British Journal of Anaesthesia·T W HahnM Rasmussen
Aug 16, 2001·Journal of Clinical Pharmacology·L P JamesUNKNOWN Pediatric Pharmacology Research Unit Network, NICHD
Jan 5, 2002·European Journal of Clinical Pharmacology·B J AndersonN H Holford
May 23, 2003·European Journal of Clinical Pharmacology·Caroline D van der MarelDick Tibboel

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Citations

Dec 12, 2012·Journal of Anaesthesiology, Clinical Pharmacology·Ranju Gandhi, Rani Sunder
Jun 18, 2019·Journal of Pain & Palliative Care Pharmacotherapy·Anne E Schweighardt, Katherine M Juba

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