The pharmacokinetics of acetyl starch as a plasma volume expander in patients undergoing elective surgery

Anesthesia and Analgesia
M BehneH Förster

Abstract

Acetyl starch (ACS) is a new synthetic colloid solution for plasma volume expansion and is now undergoing phase 2 clinical trials. We compared the pharmacokinetics of ACS with those of hydroxyethyl starch (HES) in 32 patients (ASA physical status I and II) undergoing elective surgery. In this randomized, double-blind trial, patients received either 15 mL/kg ACS 6% (average molecular weight [Mw] 200,000/molar substitution [MS] 0.5) or HES 6% (Mw 200,000/MS 0.5) i.v. up to a maximal dose of 1000 mL. Plasma colloid concentrations were measured by repetitive arterial blood sampling over 24.5 h. Plasma colloid concentrations were detected using a high-pressure liquid chromatography controlled enzymatic test. Standard pharmacokinetics were calculated, including initial half-life (t(1/2init)), i.e., the time required for a 50% decline of the maximal plasma colloid concentration at the end of drug infusion. Whereas HES was eliminated by second-order kinetics, ACS followed first-order characteristics. In the first hours after i.v. administration, t(1/2init) and clearances were similar in both groups. However, the terminal half-life of HES was significantly longer than that of ACS (9.29 +/- 1.43 h vs 4.37 +/- 1.06 h). After 16.5 and 24.5...Continue Reading

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Citations

Jan 20, 2005·The British Journal of Dermatology·K Bork
Jan 10, 2002·Journal of Pharmaceutical Sciences·Maarit TarvainenPetteri Paronen
Jan 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alireza ShalviriXiao Yu Wu
Aug 18, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laura TuovinenKristiina Järvinen
May 10, 2016·International Journal of Biological Macromolecules·Huaxi XiaoYuejiao Chen

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