The pharmacokinetics of ceftazidime in lactating and non-lactating cows

Veterinary Research Communications
R RuleP M Buschiazzo

Abstract

The pharmacokinetics of ceftazidime (CAZ) were studied in lactating (LTG) and non-lactating (NLTG) cows. Two groups (LTG and NLTG) of 5 healthy dairy cows were given ceftazidime (10 mg/ kg body weight) intravenously (i.v.) and intramuscularly (i.m.). Serum and milk (LTG) and serum samples (NLTG) were collected over a 24-h period post-administration. CAZ concentrations in serum and milk were determined by high-performance liquid chromatography, and an interactive and weighted-non-linear least-squares regression analysis was used to perform the pharmacokinetic analysis. The pharmacokinetic profiles in LTG and NLTG cows which had received CAZ i.v. fitted a three-compartment model and a two-compartment model, respectively. The CAZ concentration-time curves in serum and the area under the curve were greater and more sustained (p < 0.05) in the LTG cows by both routes, while the serum clearance (Cls = 72.5 +/- 18.1 ml/h per kg) was lower (p < 0.05) than that in the NLTG cows (Cls = 185.9 +/- 44.2 ml/h per kg). CAZ given i.v. exhibited a relatively long half-life of elimination (t1/2 beta (LTG) = 1.1 +/- 0.2 h; t1/2 beta (NLTG) = 1.4 +/- 0.3 h). Compared with other cephalosporins, CAZ had good penetration into the mammary gland (47.7 ...Continue Reading

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Citations

Jan 16, 2007·Journal of Veterinary Pharmacology and Therapeutics·L AmbrosM I San Andres
Sep 16, 2010·Journal of Veterinary Pharmacology and Therapeutics·M N Martinez, R P Hunter
Jun 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·M Martinez, S Modric
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·A MonfrinottiM Rebuelto
Feb 27, 2007·Journal of Veterinary Science·Neetu RajputHarpal S Sandhu
Jan 30, 2021·Journal of Veterinary Pharmacology and Therapeutics·Christina D McNealVirginia R Fajt

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