1 Addition of lithium carbonate (55 mmol/kg dry wt.) to the diet of rats for 4 days resulted in ratios between lithium in the brain and serum and between the cerebrospinal fluid (CSF) and serum of approx. 1 and 0.4, respectively. The relationships between the concentrations were linear. 2 After single intraperitoneal injections of lithium chloride (5 mmol/kg body wt.) the concentration of lithium in the CSF was greater than that of the brain for 2 h. 3 Repeated subcutaneous injections of lithium chloride (0.9 mmol/kg body wt.) resulted in steady state ratios corresponding to those observed when lithium was given in the diet. The rate of elimination from the CSF was intermediate between that of the serum and cerebral tissue until a new equilibrium was reached after approx. 24 h. At that time the ratios between lithium in the brain and serum, and in the CSF and serum were increased to approx. 5 and 0.8, respectively. 4 These results are consistent with passive transfer kinetics of lithium in the CSF and elimination of lithium from the cerebral tissue via the CSF. 5 The results may explain some of the phenomena observed in patients during intoxication with lithium.
The uptake of low concentrations of lithium ions into rat cerebral cortex slices and its dependence on cations
Lithium concentration in cerebrospinal fluid of affective psychotic patients treated with lithium carbonate and its clinical response
Long-term lithium administration to rats. Lithium and sodium dosage and administration, avoidance of intoxication, polyuric control rats
Measurement of tissue lithium concentration by lithium magnetic resonance spectroscopy in patients with bipolar disorder
Distribution of lithium in the rat brain after a single administration known to elicit aversive effects
Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram
Features of the comparative pharmacokinetics of lithium; a potential application of its use in livestock farming
Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome
The pharmacokinetic profile of lithium in rat and mouse; an important factor in psychopharmacological investigation of the drug
Chronic lithium administration triggers an over-expression of GRP94 stress protein isoforms in mouse liver
Study of blood and brain lithium pharmacokinetics in the rat according to three different modalities of poisoning
The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis
Sensitivity and specificity of single and combined tumour markers in the diagnosis of leptomeningeal metastasis from breast cancer
When should dialysis be performed in lithium poisoning? A kinetic study in 14 cases of lithium poisoning
The late consolidation of an aversive memory is promoted by VTA dopamine release in the dorsal hippocampus.
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CSF & Lymphatic System
This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.