The pharmacokinetics of lithium in the brain, cerebrospinal fluid and serum of the rat

British Journal of Pharmacology
O Wraae

Abstract

1 Addition of lithium carbonate (55 mmol/kg dry wt.) to the diet of rats for 4 days resulted in ratios between lithium in the brain and serum and between the cerebrospinal fluid (CSF) and serum of approx. 1 and 0.4, respectively. The relationships between the concentrations were linear. 2 After single intraperitoneal injections of lithium chloride (5 mmol/kg body wt.) the concentration of lithium in the CSF was greater than that of the brain for 2 h. 3 Repeated subcutaneous injections of lithium chloride (0.9 mmol/kg body wt.) resulted in steady state ratios corresponding to those observed when lithium was given in the diet. The rate of elimination from the CSF was intermediate between that of the serum and cerebral tissue until a new equilibrium was reached after approx. 24 h. At that time the ratios between lithium in the brain and serum, and in the CSF and serum were increased to approx. 5 and 0.8, respectively. 4 These results are consistent with passive transfer kinetics of lithium in the CSF and elimination of lithium from the cerebral tissue via the CSF. 5 The results may explain some of the phenomena observed in patients during intoxication with lithium.

References

Jul 9, 1976·Psychopharmacology·B P MukherjeeS N Pradhan
Jul 26, 1969·Lancet·A Amdisen, H Skjoldborg
Sep 8, 1972·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·L D Prockop, D J Marcus
Jun 1, 1973·Journal of Psychiatric Research·A FrazerC P Bianchi
Jul 1, 1969·Minerva anestesiologica·O ZaffiriV Contratti
Aug 30, 1969·British Medical Journal·B Hickson, D T Caridis
Feb 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·M A Baker, G Winokur
Nov 1, 1954·Journal of Neurology, Neurosurgery, and Psychiatry·M SchouH VOLDBY

Citations

Aug 1, 1994·Journal of Clinical Pharmacology·C M Swartz, P Jones
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·P Mormède, J-M Ledoux
May 4, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J C SoaresM S Keshavan
Dec 1, 1987·The Australian and New Zealand Journal of Psychiatry·J Brayley, P Yellowlees
Jan 1, 1985·Journal of Toxicology. Clinical Toxicology·A JaegerM L Jaegle
Jan 7, 2014·Psychosomatics·Ana Ivkovic, Theodore A Stern
Jun 27, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard A Komoroski, John M Pearce
Jun 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jing-Huei LeeRichard A Komoroski
Apr 26, 1991·Brain Research·C HeurteauxM Thellier
Mar 1, 1988·Biological Psychiatry·P F Renshaw, S Wicklund
Jun 5, 2012·Neuroscience Letters·Markus HillertJochen Klein
Mar 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R NciriA El Feki
Oct 31, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anne-Sophie HanakBruno Mégarbane
Feb 3, 2009·Journal of Psychiatric Practice·Elizabeth C GruenebergerDavid A Kahn
Nov 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·A TwijnstraB W Ongerboer de Visser
Jan 1, 1993·Journal of Toxicology. Clinical Toxicology·A JaegerF Flesch
Feb 8, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Huilong LuoXavier Declèves
Feb 23, 2021·The European Journal of Neuroscience·Cecilia P KramarM Flavia Barbano
Dec 26, 2001·Chemical Reviews·N J Birch

Related Concepts

Metazoa
Brain
Half-Life
Lithium
Rats, Laboratory

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.