The pharmacokinetics of methamphetamine self-administration in male and female rats

Drug and Alcohol Dependence
Alessandra Milesi-HalléS Michael Owens

Abstract

Because methamphetamine (METH) pharmacokinetics after single iv doses show significant differences between male and female rats, we hypothesized that pharmacokinetic differences in METH disposition could be a contributing factor to the patterns of METH self-administration behaviors in rats. For the studies, we used a passive (non-contingent) METH dosing schedule consisting of 27 METH iv bolus injections (0.048mg/kg) over 2h derived from a previous active (contingent) METH self-administration behavioral study in male rats. After METH dosing of male and female Sprague-Dawley rats (n=5/group), METH and amphetamine serum concentrations were determined by LC-MS/MS. Pharmacokinetic analysis, including predictive mathematical simulations of the data, was then conducted. Male and female rats achieved relatively stable METH serum concentrations within 20min, which remained constant from 20 to 120min. While not statistically different, METH clearance and volume of distribution values for females were 25% and 33% lower (respectively) than males. Linear regression analysis of predicted METH concentrations from pharmacokinetic simulations versus observed concentrations showed a substantially better correlation with male data than female dat...Continue Reading

References

Feb 1, 1985·Journal of Pharmaceutical Sciences·F C LamD G Perrier
May 26, 1999·Behavioural Brain Research·V Quiñones-JenabM J Kreek
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J B Becker
Jul 10, 2001·Psychopharmacology·S D ComerM W Fischman
Aug 21, 2001·Psychopharmacology·C L HartM W Fischman
Feb 21, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Chyan E Lau, Lei Sun
Jun 18, 2002·European Journal of Pharmacology·Charles W SchindlerEric B Thorndike
Nov 11, 2003·Trends in Pharmacological Sciences·Edwin H JacobsAnton N M Schoffelmeer
Mar 3, 2004·The Journal of Pharmacology and Experimental Therapeutics·D E McMillanS M Owens
Jun 3, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·H P HendricksonS M Owens
May 27, 2005·Toxicology and Applied Pharmacology·Alessandra Milesi-HalléS Michael Owens
Jan 18, 2006·Drug and Alcohol Dependence·Jolan M Terner, Harriet de Wit
Feb 6, 2007·Pharmacology, Biochemistry, and Behavior·Alessandra Milesi-HalléS Michael Owens
Feb 13, 2010·Addiction·Andrea R VansickelCraig R Rush
Jun 15, 2013·Psychoneuroendocrinology·Brittney M CoxCarmela M Reichel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.