Jan 1, 1989

The pharmacokinetics of midazolam in paediatric patients

European Journal of Clinical Pharmacology
K PayneT Dawes

Abstract

A serum concentration profile study on midazolam in children was done. Fifty six children aged 3-10 years took part. The routes investigated were intravenous, intramuscular, rectal and oral at 0.15 mg.kg-1, and the oral at 0.45 mg.kg-1 and 1 mg.kg-1. Serum concentration levels for 5 h were studied using gas liquid chromatography. The volume of distribution, Vss, was 1.29 l.kg-1, the elimination half-life 1.17 h and the serum clearance 9.11 ml.kg-1.min-1. Peak serum concentrations for the intramuscular, rectal and oral routes were at 15 min, 30 min and 53 min respectively. Bioavailability was 87%, 18%, 27% respectively at a dose of 0.15 mg.kg-1. The oral route bioavailability halved to 15% at the two higher doses. Bioequivalence was present between the 0.15 mg.kg-1 intramuscular dose and the 0.45 mg.kg-1 oral dose from 45 to 120 min.

  • References28
  • Citations86

Citations

Mentioned in this Paper

Intravenous Injections
Pediatric Discipline
Silicic Acid
Drug Interactions
Chromatography, Gas-Liquid
Midazolam
Versed
Magnesium Silicates
Magnesium trisilicate tetrahydrate (Mg4(H6Si6O19))
Half-Life

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