PMID: 7334461Oct 1, 1981Paper

The pharmacokinetics of penicillamine in a female mongrel dog

Journal of Pharmacokinetics and Biopharmaceutics
R F BergstromJ G Wagner

Abstract

The pharmacokinetic parameters of D-penicillamine were investigated by administering four intravenous bolus doses, four oral doses, and six constant rate intravenous infusions to a female mongrel dog at dosages comparable to 250, 500, 750, and 1000 mg in man. The pharmacokinetics of D-penicillamine demonstrated nonlinearity in the dog. There was more than proportional increase in the area under the whole blood concentration curve for an increase in the bolus intravenous dose. The steady state whole blood, plasma, and packed cells levels of penicillamine were increased more than proportionately for an increase in the intravenous infusion rate. Total body clearance of penicillamine was decreased by increasing the dose or the infusion rate of penicillamine. Correspondingly, the estimated half-life of unchanged penicillamine in the whole blood was decreased for increased intravenous bolus doses. The renal clearance of penicillamine was nonlinear, decreasing with time during the bolus experiments and increasing at higher infusion rates. The nonrenal clearance was decreased at higher infusion rates, suggesting that a saturable nonrenal elimination process exists for penicillamine in the dog. The nonlinearities that were observed in t...Continue Reading

References

Jul 1, 1976·Journal of Pharmaceutical Sciences·A J Sedman, J G Wagner
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Aug 1, 1975·British Journal of Clinical Pharmacology·J D RobinsonV Marks
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Sep 1, 1981·Clinical Pharmacology and Therapeutics·R F BergstromJ G Wagner
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Oct 1, 1956·The American Journal of Medicine·J M WALSHE

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Citations

Jan 1, 1989·Pharmacology & Therapeutics·D A Joyce
Nov 1, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·E LipkaG L Amidon
Jul 25, 2009·Journal of Veterinary Internal Medicine·G HoffmannJ Rothuizen
Jul 24, 2013·Journal of Veterinary Internal Medicine·D K LangloisW D Schall
Jan 1, 1989·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·W C Eckelman
Sep 1, 1984·Journal of Pharmaceutical Sciences·W G ChamblissA H Kibbe
May 21, 2010·Clinical Pharmacokinetics·Neal M DaviesJaime A Yáñez
Mar 8, 2019·Journal of Veterinary Internal Medicine·Cynthia R L WebsterPenny J Watson

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