PMID: 8613563Dec 1, 1995Paper

The pharmacokinetics of phenytoin in gingival crevicular fluid and plasma in relation to gingival overgrowth

Journal of Clinical Periodontology
W S McLaughlinK White

Abstract

The aim of this study was to determine whether phenytoin (PHT) could be detected in gingival crevicular fluid (GCF), and to relate its concentration to both plasma level and degree of gingival overgrowth. 23 patients medicated with phenytoin for at least 6 months were clinically examined for signs of periodontal disease and gingival overgrowth. 12 patients out of these demonstrated clinically significant overgrowth and their plaque scores and gingival inflammation were greater than for the non-overgrowth group (p < 0.001). Phenytoin concentrations were determined by high performance liquid chromatography, and was detected in GCF. There was a significant correlation between the GCF and plasma phenytoin concentrations (p < 0.05), but it was not related to the extent of gingival overgrowth. Inflammation increased the GCF volume, but was not a determinant of GCF phenytoin concentration. It is concluded that effusion of phenytoin into GCF is regulated by the plasma levels of the drug, but its concentration in GCF is not related to the incidence of gingival overgrowth.

References

Aug 1, 1975·Developmental Medicine and Child Neurology·T M LittleR E Masotti
Oct 1, 1992·Community Dentistry and Oral Epidemiology·J M ThomasonM D Rawlins
Jul 1, 1985·Journal of Clinical Periodontology·R A SeymourD N Turnbull
Dec 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·A P Angelopoulos, P W Goaz
Jan 1, 1973·Journal of Public Health Dentistry·L A Klar
Aug 1, 1973·Developmental Medicine and Child Neurology·R N KapurR E Masotti
Nov 1, 1971·Journal of Pharmaceutical Sciences·G J ConardK F Finger
Jul 6, 1971·Annals of the New York Academy of Sciences·L LundF Sjöqvist
Jun 1, 1983·Journal of Periodontology·V AddyP F D'Arcy
Apr 1, 1984·Journal of Clinical Periodontology·T HassellH Best
Jan 1, 1981·Journal of the American Academy of Child Psychiatry·W A SonisE T Richey

❮ Previous
Next ❯

Citations

Jan 14, 2000·Journal of Periodontal Research·R B JohnsonM A Tucci
Aug 10, 2001·Journal of Periodontology·M I UzelP C Trackman
Jan 11, 2007·Journal of Periodontology·Güliz N GüncüErdem Karabulut
Nov 17, 2009·Journal of the Indian Society of Pedodontics and Preventive Dentistry·S Mukhopadhyay
Aug 15, 2012·Fundamental & Clinical Pharmacology·Reiri TakeuchiAkira Fujii
Apr 27, 2010·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Renata de Oliveira GuaréMaria Teresa Botti Rodrigues Dos Santos
Oct 13, 2011·ISRN Dentistry·Jôice Dias CorrêaTarcilia Aparecida Silva
Jun 10, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C Trackman, A Kantarci
Mar 4, 2000·Medical & Biological Engineering & Computing·M CostaE Ducla-Soares

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.