PMID: 729620Dec 1, 1978

The pharmacokinetics of slow-release procainamide

European Journal of Clinical Pharmacology
W J TilstoneT D Lawrie

Abstract

Procainamide was given to 20 patients with normal renal function as an i.v. bolus of 500 mg followed by 1.0 or 1.5 g eight-hourly by mouth in the form of a slow release preparation (Durules). 97.6 +/- 27.1 (SD)% of the oral procainamide was absorbed, the absorption half life being 1.54 h. The elimination half life following the oral formulation was 6.0 +/- 0.8 h, compared to a mean of 3.4 +/- 0.4 h following i.v. administration. Elimination half life following i.v. administration was slightly related to acetylator status, being 2.75 +/- 0.9 h in fast acetylators, and 4.4 +/- 2.4 h in slow acetylators. This dependence on acetylator status was not seen in half life following oral administration. Total body clearance, steady state plasma procainamide and N-acetylprocainamide were not significantly dependent on acetylator status, although a few patients who are slow acetylators had unexpectedly low clearance and high steady state procainamide concentrations when given the higher dose.

References

Jan 1, 1978·Clinical Pharmacology and Therapeutics·J J Lima, W J Jusko
Aug 1, 1975·The Journal of Infectious Diseases·M BarzaL Weinstein
Oct 1, 1977·British Journal of Clinical Pharmacology·D H Lawson, H Jick
Sep 1, 1976·Clinical Pharmacology and Therapeutics·R L GaleazziL B Sheiner
Apr 1, 1975·Clinical Pharmacology and Therapeutics·C GraffnerJ Sjögren
Mar 11, 1976·Clinical Pharmacology and Therapeutics·E G GiardinaE C Schreiber
Mar 1, 1971·JAMA : the Journal of the American Medical Association·J Koch-Weser, S W Klein
Dec 1, 1969·Journal of Medical Genetics·D A Evans
Dec 1, 1976·British Journal of Clinical Pharmacology·W CampbellT D Lawrie

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·P YlitaloT Metsä-Ketelä
Feb 28, 1979·Psychopharmacology·W J TilstoneE C Johnstone

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