PMID: 15220698Jun 29, 2004Paper

The pharmacokinetics, safety, and initial virologic response of a triple-protease inhibitor salvage regimen containing amprenavir, saquinavir, and ritonavir

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Amanda H CorbettAngela D M Kashuba

Abstract

The aim of this study was to quantify the change in saquinavir and amprenavir exposure when combined and used with low-dose ritonavir; to evaluate 24-week safety and immunologic and virologic response. It was a randomized, nonblinded, prospective study. There were 11 HIV-1-infected, antiretroviral-experienced, male and female subjects > or = 18 years old, median HIV-1 RNA and CD4(+) T-cell count of 4.86 log copies/mL and 10(6) cells/mm(3), respectively. Subjects were randomly assigned to receive saquinavir 1000 mg/ritonavir 100 mg every 12 hours or amprenavir 600 mg/ritonavir 100 mg every 12 hours for 7 days. After 12-hour pharmacokinetic sampling, the third protease inhibitor (PI) was added, and pharmacokinetics sampling was repeated 14 days later. Subsequent PI dosage adjustments were based on real-time pharmacokinetic assessment. Saquinavir did not affect amprenavir or ritonavir pharmacokinetics. Amprenavir decreased area under the concentration-time curve (AUC(0-12h)) and C(12h) for saquinavir 82 and 61%, and 74 and 75% for ritonavir. An adjusted PI regimen of amprenavir 600 mg/saquinavir 1400 mg/ritonavir 200 mg every 12 hours returned saquinavir exposure to baseline. At 24 weeks, HIV RNA declined a median of 1.55 log copi...Continue Reading

References

Jul 27, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A I VeldkampR M Hoetelmans
Feb 5, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·V A EaglingD J Back
Dec 24, 2002·Clinical Pharmacology and Therapeutics·Jonathan Q TranBradley M Kerr

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Citations

Oct 12, 2010·AIDS Research and Human Retroviruses·Regina B OsihUNKNOWN Swiss HIV Cohort Study
Jul 28, 2006·Antimicrobial Agents and Chemotherapy·Amanda H CorbettAngela D M Kashuba
Jun 7, 2005·Expert Opinion on Emerging Drugs·Erik De Clercq
May 14, 2008·HIV Clinical Trials·Ann C CollierUNKNOWN AIDS Clinical Trials Group Protocol A5143 Team
Mar 12, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Simone TenoreRicardo Sobhie Diaz
Jan 14, 2005·Current Opinion in Infectious Diseases·Marta BoffitoAnton Pozniak

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