PMID: 8941865Oct 1, 1996Paper

The pharmacological basis for the use of dried sheep placenta in traditional obstetric practice in Nigeria

Journal of Ethnopharmacology
G Onuaguluchi, S Ghasi

Abstract

Dried sheep placenta is sometimes used in traditional medicine to facilitate labour. The effects of an extract of powdered dried sheep placenta with normal saline on guinea-pig uterus, ileum, spontaneously beating atrium and Langendorff heart, rat uterus and hindquarters, and cat blood pressure were therefore examined. It was found that 1 g of dried sheep placenta had, on the guinea-pig uterus, an oxytocic activity equipotent with 0.075-0.32 i.u. of oxytocin. The oxytocic activity was unaffected at pHs between 4 and 10 or by boiling for 30 min or autoclaving for 15 min. Neither atropine nor promethazine inhibited the oxytocic action, but promethazine inhibited, to the same degree, contractions induced in the ileum by equipotent doses of the infusion and histamine. Atropine, however, had no effect on infusion-induced contractions in the ileum. The vasoconstriction induced in the rat hindquarters was antagonized by promethazine and phentolamine. Cat blood pressure was reduced, but it had positive inotropic and chronotropic effects on the spontaneously beating guinea-pig atrium and on the guinea-pig Langendorff heart. It was concluded that the dried placenta contains a chorionic oxytocic substance the action of which is independen...Continue Reading

References

Jul 22, 1993·Annals of the New York Academy of Sciences·D C WathesV J Ayad

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Citations

Nov 25, 2000·Journal of Ethnopharmacology·G Onuaguluchi, I S Ogbu
Feb 14, 2012·Obstetrical & Gynecological Survey·L Lewis Wall
Dec 15, 2012·Studies in Family Planning·L Lewis Wall
Jun 6, 2015·Archives of Women's Mental Health·Cynthia W CoyleCrystal T Clark
Nov 22, 2005·British Journal of Pharmacology·David J R FosterAllison Martinez
Nov 18, 2018·Malaria Journal·Adélaïde CompaoréKoen Peeters Grietens

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