The pharmacological management of patients with comorbid psoriasis and obesity

Expert Opinion on Pharmacotherapy
Andrea ChiricozziG Girolomoni

Abstract

Psoriasis is a chronic inflammatory skin disease that is increasingly being recognized as a complex disorder affecting multiple systems. Systemic inflammation is considered the pathogenic link between psoriasis and its comorbid conditions that include arthritis, metabolic disorders, depression, and cardiovascular diseases. The presence of comorbid conditions modifies both its clinical management and the therapeutic approach in psoriatic patients. This review describes the clinical, epidemiological, and pathogenic link between psoriasis and obesity. Furthermore, data related to the effects of synthetic antipsoriatic drugs on obesity are collated. Obesity is one of the most common comorbid conditions that is relevant both for a patient's overall health and the clinical outcomes of antipsoriatic therapies. Indeed, some treatments of psoriasis might be impaired by adiposity. Moreover, obesity's association with dyslipidemia, hypertension, and increased liver enzymes could further be worsened by acitretin, cyclosporine and methotrexate, respectively. Therefore, the identification of therapeutic targets whose blockade could have positive effects on both psoriasis and mechanisms regulating body weight homeostasis may be of great relev...Continue Reading

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Citations

Mar 21, 2020·Dermatologic Therapy·Ricardo Ruiz-VillaverdeJose Carlos Ruiz-Carrascosa
May 18, 2020·Current Obesity Reports·Kyriaki ParoutoglouMaria Dalamaga
Sep 6, 2020·Dermatologic Therapy·Paolo GisondiGiampiero Girolomoni
Jun 10, 2020·Korean journal of family medicine·Adrian Martinez-MorenoVeronica Garza-Rodriguez

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