The pharmacological potential of Sorbus commixta cortex on blood alcohol concentration and hepatic lipid peroxidation in acute alcohol-treated rats

The Journal of Pharmacy and Pharmacology
Syng-Ook LeeHyo Gwon Im

Abstract

The effect of Sorbus commixta cortex, a traditional herbal medicine used for the treatment of bronchitis, gastritis and dropsy, on blood alcohol concentration (BAC) and hepatic lipid peroxidation was examined in acute alcohol-treated rats. A 30-min pretreatment with a methanol extract of S. commixta cortex (SC) at concentrations higher than 200 mg kg(-1) resulted in a significant decrease in BAC and the ethyl acetate fraction (SE) of the extract showed the highest potency, with a maximum of a 46% decrease at 150 mg kg(-1) 2 h after alcohol administration (3.0 g kg(-1)) compared with the control group (P < 0.005). The rapid reduction in BAC did not appear to be due to the protection or activation of hepatic alcohol dehydrogenase (ADH) activity by SE. Hepatic malondialdehyde (MDA) levels were significantly increased by acute alcohol administration within 6 h, although pretreatment with the SE caused a significant decrease in MDA levels compared with alcohol treatment alone. Hepatic glutathione (GSH) levels and superoxide dismutase (SOD) activity remained unchanged by alcohol, SE alone or by the combined treatment of alcohol and SE. However, catalase activity was significantly reduced by acute alcohol administration and pretreatme...Continue Reading

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Citations

Aug 22, 2014·Natural Product Research·Lina RaudonėValdimaras Janulis
Mar 19, 2014·Natural Product Research·Raimondas RaudonisValdimaras Janulis
Feb 10, 2017·Journal of Food Science·Maja Mikulic-PetkovsekRobert Veberic
Dec 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lok Ranjan BhattKyu Yun Chai
Jun 25, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Minkyun NaJong Seog Ahn
Jun 7, 2017·International Journal of Molecular Medicine·Hyerin ParkKi-Tae Ha

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