The pharmacological properties of Ophiocordyceps xuefengensis revealed by transcriptome analysis

Journal of Ethnopharmacology
Jian JinShuihan Zhang

Abstract

The Yao ethnic group in Xuefeng Mountains area have used Xuefeng cordyceps, the caterpillar-fungus complex of Ophiocordyceps xuefengensis, for treating a variety of diseases for long. Just like some other cordyceps, O. xuefengensis, which is identified as the sister taxon of O. sinensis in 2013, also seems to have broad pharmacological properties, not only enhancing human immunity, anti-bacteria, anti-virus, but also anti-tumor. However, investigation of the medicinal fugal species O. xuefengensis can be found only in few literature records since its pharmacological and therapeutic use is mainly in traditional Yao communities by local healers. The aim of this study is to collect samples of Xuefeng cordyceps and isolate the strain of O. xuefengensis, to determine bioactive components and evaluate the anti-tumor activity, to obtain the gene expression profile of O. xuefengensis and reveal its pharmacological properties by de novo transcriptome analysis. Accordingly, we attempt to provide information and give a comprehensive understanding of this mysterious medicinal fugal species from traditional Yao communities of China. Bioactive components were determined with HPLC-DAD-Q-TOF-MS technology; in vitro anti-tumor activity against ...Continue Reading

Citations

May 8, 2019·FEMS Microbiology Letters·Juan ZouZuo-Hong Chen
Jun 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peng QinDengXue Lu
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian JinLuqi Huang
Nov 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian JinYuhui Qin
Nov 8, 2020·Phytochemistry·You QinShui-Han Zhang

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