PMID: 10934997Aug 10, 2000Paper

The pharmacology of anesthetic drugs in elderly patients

Anesthesiology Clinics of North America
S L Shafer

Abstract

Elderly patients are more sensitive to anesthetic drugs than younger patients. This increased sensitivity has a pharmacokinetic basis if the dose produces a higher drug concentration in an elderly patient than in a younger patient. The increased sensitivity has a pharmacodynamic basis if the same concentration produces a more profound drug effect in elderly patients. This article reviews the mechanisms of increased sensitivity of elderly patients to opioids, hypnotics, amnestica, and muscle relaxants.

Associated Clinical Trials

References

May 1, 1979·British Journal of Anaesthesia·K McLeodM J Watson
May 1, 1979·Anesthesia and Analgesia·G M Bennett, T H Stanley
Jul 1, 1977·Journal of Gerontology·H Bafitis, F Sargent
Mar 1, 1976·Anesthesia and Analgesia·W LiuJ Isern-Amaral
Jan 1, 1975·Acta Anaesthesiologica Scandinavica·L ThulinL Irestedt
Nov 1, 1992·British Journal of Anaesthesia·C J ParkerS L Snowdon
Jan 1, 1992·Anesthesiology·H J LemmensM P Gladines
Nov 1, 1991·British Journal of Anaesthesia·J E FairfieldR J Beale
Aug 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·P O MaitreD R Stanski
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R E CowanR P Thompson
Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R S MatteoW J Chang
Nov 1, 1990·Clinical Pharmacokinetics·H J LemmensJ G Bovill
Feb 1, 1990·Anesthesiology·J B KittsR D Miller
Dec 1, 1989·British Journal of Anaesthesia·A P KentJ M Hunter
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H A WynneO F James
Jan 1, 1989·British Journal of Anaesthesia·G L ScheepstraL G Coenen
Feb 12, 1986·The American Journal of Cardiology·J L Fleg
Jul 1, 1986·Anesthesia and Analgesia·N D KienJ H Eisele
Jan 1, 1987·The Journal of Pharmacology and Experimental Therapeutics·J C Scott, D R Stanski
Aug 1, 1988·British Journal of Anaesthesia·H J LemmensP J Hennis
Oct 1, 1988·Anesthesia and Analgesia·H J LemmensA G Burm
Nov 1, 1988·Journal of Clinical Pharmacology·A A HolazoI H Patel
Feb 1, 1988·British Journal of Anaesthesia·T KirkpatrickW S Nimmo
May 1, 1988·British Journal of Anaesthesia·M A SingletonD M Fisher
Feb 1, 1985·British Journal of Clinical Pharmacology·D DavisP A Routledge
Apr 1, 1985·Acta Anaesthesiologica Scandinavica·L TokicsG Hedenstierna
Sep 1, 1970·Metabolism: Clinical and Experimental·G B Forbes, J C Reina
Apr 1, 1982·Anesthesia and Analgesia·R A UptonN Castagnoli
Jun 1, 1982·British Journal of Anaesthesia·A d'HollanderS Agoston
Jan 1, 1981·British Journal of Anaesthesia·R Hughes, D J Chapple
Jan 1, 1983·Journal of Chronic Diseases·J Crooks
Jan 1, 1984·Gerontology·M E LeitheC V Leier

❮ Previous
Next ❯

Citations

Jun 24, 2003·Best Practice & Research. Clinical Anaesthesiology·Mihai R Sadean, Peter S A Glass
Jun 11, 2008·Drugs & Aging·Margaret EksteinAvi A Weinbroum
Dec 3, 2014·The Surgical Clinics of North America·Elie RamlyGeorge C Velmahos
Jan 29, 2013·Anesthesiology Clinics·Shawn E Banks, Michael C Lewis
Nov 10, 2015·Clinical Therapeutics·Adam T PhillipsMatthew A Levin
May 31, 2011·Anesthesiology Clinics·Kishor GandhiEugene R Viscusi
Apr 3, 2007·Anesthesiology Clinics·Michael C LewisMiguel Paniagua
Sep 1, 2015·Anesthesiology Clinics·Shamsuddin Akhtar, Ramachandran Ramani
Jul 16, 2013·The Journal of Arthroplasty·Joseph D LamplotDavid W Manning
Sep 27, 2005·AIDS·Philippe LemeyAnne-Mieke Vandamme
May 23, 2003·Anesthesia and Analgesia·David J Cook, G Alec Rooke
Apr 9, 2005·European Journal of Anaesthesiology·S KreuerW Wilhelm
Nov 24, 2004·Drugs & Aging·Ban C H TsuiBrendan Finucane
Oct 5, 2006·Current Opinion in Anaesthesiology·Stanley Muravchick
Jun 10, 2011·The Journal of Bone and Joint Surgery. American Volume·Javad ParviziKishor Gandhi
Dec 1, 2017·Current Opinion in Anaesthesiology·Shamsuddin Akhtar
Nov 13, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Nina FisherKenneth A Egol
Jun 26, 2003·Alimentary Pharmacology & Therapeutics·L T HeussC Beglinger
Jun 11, 2016·Molecular and Clinical Oncology·Keita KouzuKazuo Hase
Jul 12, 2020·Aging Clinical and Experimental Research·Paola AcetoUNKNOWN Società Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI), Società Italiana di Gerontologia e Geria
Mar 16, 2017·The Journal of Bone and Joint Surgery. American Volume·Daniel KoehlerMichael Willey
Mar 10, 2009·Dental Clinics of North America·John M Coke, Michael D Edwards

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Best Practice & Research. Clinical Anaesthesiology
Jaap Vuyk
Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
S R Gambert
© 2022 Meta ULC. All rights reserved