PMID: 10934997Aug 10, 2000Paper

The pharmacology of anesthetic drugs in elderly patients

Anesthesiology Clinics of North America
S L Shafer


Elderly patients are more sensitive to anesthetic drugs than younger patients. This increased sensitivity has a pharmacokinetic basis if the dose produces a higher drug concentration in an elderly patient than in a younger patient. The increased sensitivity has a pharmacodynamic basis if the same concentration produces a more profound drug effect in elderly patients. This article reviews the mechanisms of increased sensitivity of elderly patients to opioids, hypnotics, amnestica, and muscle relaxants.

Associated Clinical Trials


May 1, 1979·British Journal of Anaesthesia·K McLeodM J Watson
May 1, 1979·Anesthesia and Analgesia·G M Bennett, T H Stanley
Jul 1, 1977·Journal of Gerontology·H Bafitis, F Sargent
Mar 1, 1976·Anesthesia and Analgesia·W LiuJ Isern-Amaral
Jan 1, 1975·Acta Anaesthesiologica Scandinavica·L ThulinL Irestedt
Nov 1, 1992·British Journal of Anaesthesia·C J ParkerS L Snowdon
Jan 1, 1992·Anesthesiology·H J LemmensM P Gladines
Nov 1, 1991·British Journal of Anaesthesia·J E FairfieldR J Beale
Aug 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·P O MaitreD R Stanski
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R E CowanR P Thompson
Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R S MatteoW J Chang
Nov 1, 1990·Clinical Pharmacokinetics·H J LemmensJ G Bovill
Feb 1, 1990·Anesthesiology·J B KittsR D Miller
Dec 1, 1989·British Journal of Anaesthesia·A P KentJ M Hunter
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H A WynneO F James
Jan 1, 1989·British Journal of Anaesthesia·G L ScheepstraL G Coenen
Feb 12, 1986·The American Journal of Cardiology·J L Fleg
Jul 1, 1986·Anesthesia and Analgesia·N D KienJ H Eisele
Jan 1, 1987·The Journal of Pharmacology and Experimental Therapeutics·J C Scott, D R Stanski
Aug 1, 1988·British Journal of Anaesthesia·H J LemmensP J Hennis
Oct 1, 1988·Anesthesia and Analgesia·H J LemmensA G Burm
Nov 1, 1988·Journal of Clinical Pharmacology·A A HolazoI H Patel
Feb 1, 1988·British Journal of Anaesthesia·T KirkpatrickW S Nimmo
May 1, 1988·British Journal of Anaesthesia·M A SingletonD M Fisher
Feb 1, 1985·British Journal of Clinical Pharmacology·D DavisP A Routledge
Apr 1, 1985·Acta Anaesthesiologica Scandinavica·L TokicsG Hedenstierna
Sep 1, 1970·Metabolism: Clinical and Experimental·G B Forbes, J C Reina
Apr 1, 1982·Anesthesia and Analgesia·R A UptonN Castagnoli
Jun 1, 1982·British Journal of Anaesthesia·A d'HollanderS Agoston
Jan 1, 1981·British Journal of Anaesthesia·R Hughes, D J Chapple
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Jan 1, 1984·Gerontology·M E LeitheC V Leier

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