PMID: 9184794May 1, 1997Paper

The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord

General Pharmacology
A H DickensonG M Green

Abstract

1. The aim of this review is to consider the relative roles of inhibitory and excitatory amino acid receptor-mediated events in the processes leading to pain transmission in the spinal cord. 2. Emphasis will be on the roles of the inhibitory and excitatory amino acids, GABA and glutamate, and how the relative balance between activity in these systems appears to determine the level of pain transmission. 3. The N-methyl-D-aspartate (NMDA) receptor for glutamate has been implicated in the generation and maintenance of central (spinal) states of hypersensitivity. It has been shown that activation of this receptor underlies wind-up, whereby the level of transmission of noxious messages is potentiated. Antagonists at this receptor-channel complex prevent or block enhanced (hyperalgesic) pain states induced by tissue damage, inflammation, nerve damage and ischemia. 4. Information concerning amplification systems in the spinal cord, such as the NMDA receptor, is a step toward understanding why and how a painful response is not always matched to the stimulus. Such events have parallels with other plastic events such as long-term potentiation (LTP) in the hippocampus. 5. However, the roles of inhibitory transmitter systems can also chang...Continue Reading

References

Dec 1, 1992·Trends in Pharmacological Sciences·W Sieghart
Jun 1, 1992·Current Opinion in Neurobiology·Z I Bashir, G L Collingridge
Dec 1, 1990·Trends in Pharmacological Sciences·E A Barnard, J M Henley
Nov 8, 1988·The Journal of Comparative Neurology·G Battaglia, A Rustioni
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·J Sawynok
Mar 1, 1980·The Journal of Pharmacy and Pharmacology·G A JohnstonC G Freeman
Feb 1, 1984·British Journal of Pharmacology·M DésarmenienR Schlichter
Feb 1, 1980·Postgraduate Medical Journal·D J Lipscomb, T J Meredith
Dec 1, 1994·British Journal of Pharmacology·M Malcangio, N G Bowery
Mar 3, 1995·Neuroscience Letters·D R SimmonsA J Todd
Sep 1, 1994·Trends in Pharmacological Sciences·J Watkins, G Collingridge
Mar 1, 1994·Trends in Pharmacological Sciences·L StanfaZ Wiesenfeld-Hallin
Aug 27, 1993·Brain Research·J M Castro-LopesA Coimbra
Jan 1, 1991·The European Journal of Neuroscience·Hans-Georg SchaibleMaria Oppmann

❮ Previous
Next ❯

Citations

Mar 10, 2005·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Håkan Alfredson, Lars Ohberg
Aug 13, 2005·Der Schmerz·W Koppert
Jun 7, 2011·Journal of Neural Transmission·Arpád PárdutzLászló Vécsei
Jul 4, 2002·Current Pain and Headache Reports·Rie Suzuki, Anthony H Dickenson
Dec 17, 2011·Journal of Molecular Neuroscience : MN·Pawel LisowskiArtur H Swiergiel
Oct 31, 2009·Molecular Neurobiology·Max Larsson
Jan 20, 2004·European Journal of Pharmacology·Patricia G da MottaMaria Aparecida K F Tatsuo
Jan 20, 2004·European Journal of Pharmacology·María Irene Díaz-RevalFrancisco Javier López-Muñoz
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Mauricio MondacaRubén Soto-Moyano
Jul 19, 2000·Brain Research·F Bordi, A Ugolini
Nov 8, 2001·European Journal of Pharmacology·C G Parsons
Sep 27, 2003·European Journal of Pharmacology·Teresa PelissierCarlos Paeile
Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Mar 14, 2001·Brain Research. Brain Research Reviews·D D Mitsikostas, M Sanchez del Rio
Feb 15, 2001·Brain Research. Developmental Brain Research·C E UrchA H Dickenson
Sep 23, 2000·Brain Research. Molecular Brain Research·F Lourenço NetoJ M Castro-Lopes
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 23, 1999·Progress in Neurobiology·F Bordi, A Ugolini
Mar 8, 2000·Progress in Neurobiology·J F HerreroJ A López-García
May 22, 2003·Neuroscience Letters·Luis ConstandilAlejandro Hernández
Oct 16, 2001·Burns : Journal of the International Society for Burn Injuries·N AltierM Choinière

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.