Aug 1, 1976

The pharmacology of flazalone: a new class of anti-inflammatory agent

The Journal of Pharmacology and Experimental Therapeutics
L Levy, D McClure

Abstract

The anti-inflammatory activity of flazalone, a unique chemical drug, is described. In acute irritant anti-inflammatory tests, flazalone exhibited a wide spectrum of activity. The compound was active in affecting the course of paw swelling in adjuvant arthritis when given daily either at the outset of the polyarthritis or after induction. The most unusual aspect of this compound is its ability to inhibit graft rejection in goldfish and rabbits. The pattern of anti-inflammatory activity does not allow one to classify this drug in the usual groups.

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Mentioned in this Paper

Arthritis, Experimental
Anti-Inflammatory Agents
Passive Cutaneous Anaphylaxis
Graft Vs Host Reaction
Piperidines
Rheumatoid Arthritis
Arthus Reaction
Anasarca
Adrenalectomy
Arthritis

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