The pharmacology of vesamicol: an inhibitor of the vesicular acetylcholine transporter

General Pharmacology
C PriorS M Parsons

Abstract

1. Vesamicol (2-[4-phenylpiperidino] cyclohexanol) inhibits the transport of acetylcholine into synaptic vesicles in cholinergic nerve terminals. 2. Recent pharmacological studies of the effects of vesamicol on skeletal neuromuscular transmission have revealed a pattern of activity for the compound consistent with the neurochemical observation of the mechanism of action of the compound. 3. Pharmacological manipulation of vesicular acetylcholine transport has been used to investigate the recycling and mobilization of synaptic vesicles within cholinergic nerve terminals. 4. In addition to its effects on vesicular acetylcholine transport, vesamicol also possesses some sodium channel and alpha-adrenoceptor blocking activity. 5. Vesamicol clearly represents a unique tool for investigating presynaptic mechanisms in cholinergic nerve terminals.

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Citations

May 13, 2004·Journal of Pharmaceutical and Biomedical Analysis·Mohamed M Hefnawy, Hassan Y Aboul-Enein
Oct 9, 2002·Journal of Pharmaceutical and Biomedical Analysis·Meng Zhou, James T Stewart
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sitt Wai FongGuy S Bewick
Dec 11, 2013·International Journal of Molecular Imaging·Maxime J ParentPedro Rosa-Neto
Mar 6, 2010·Journal of Neurochemistry·Ricardo de Freitas LimaChristopher Kushmerick
Feb 16, 2013·The Biochemical Journal·Vania F PradoMarco A M Prado
Jun 12, 2016·Neuroscience Letters·Alexander E GaydukovOlga P Balezina
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Dec 21, 2019·Chemistry : a European Journal·Delfino Chamorro-ArenasFernando Sartillo-Piscil
Feb 5, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joshua M BradnerGary W Miller

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