PMID: 16511612Mar 3, 2006Paper

The pharmacotherapy of chronic pain: a review

Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur
Mary E Lynch, C Peter N Watson

Abstract

The past two decades have contributed a large body of preclinical work that has assisted in our understanding of the underlying pathophysiological mechanisms that cause chronic pain. In this context, it has been recognized that effective treatment of pain is a priority and that treatment often involves the use of one or a combination of agents with analgesic action. The current review presents an evidence-based approach to the pharmacotherapy of chronic pain. Medline searches were done for all agents used as conventional treatment in chronic pain. Published papers up to June 2005 were included. The search strategy included randomized, controlled trials, and where available, systematic reviews and meta-analyses. Further references were found in reference sections of papers located using the above search strategy. Agents for which there were no controlled trials supporting efficacy in treatment of chronic pain were not included in the present review, except in cases where preclinical science was compelling, or where initial human work has been positive and where it was thought the reader would be interested in the scientific evidence to date.

Citations

Jun 18, 2010·The Korean Journal of Pain·Hue Jung Park, Dong Eon Moon
Nov 19, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Paul S Tumber
Oct 11, 2017·Scandinavian Journal of Pain·Kehua ZhouGary G Wang
Feb 25, 2018·Current Pain and Headache Reports·Mark R JonesJoshua A Hirsch
Aug 1, 2006·Photomedicine and Laser Surgery
Sep 23, 2014·Current Medical Research and Opinion·Charles E Argoff, Ernest A Kopecky
Sep 10, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Shanky GargPranav Prasoon
Aug 13, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·James ElliottGwendolen Jull
Aug 28, 2020·Frontiers in Neuroscience·Milena DuitamaYolima P Torres
Jul 29, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Orlando HungAlexander J Clark
Feb 15, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Henrica R Schiphorst PreuperMichiel F Reneman
Apr 16, 2014·Pharmacoepidemiology and Drug Safety·Marsha A RaebelWilliam Troy Donahoo
Dec 9, 2015·Proceedings of the National Academy of Sciences of the United States of America·Alina Y RweiDaniel S Kohane
Sep 18, 2014·Drugs & Aging·Mary-Ann FitzcharlesDavid Lussier
Mar 18, 2010·Anesthesiology·Dermot R FitzgibbonKaren B Domino
Sep 26, 2020·Annual Review of Pharmacology and Toxicology·Dorien BampsThomas Voets
Jan 14, 2021·Drug Testing and Analysis·Fernando MoreiraMaria de Lourdes Bastos
Nov 19, 2020·Pharmacological Reviews·Muhammad Saad YousufTheodore J Price
Jan 28, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jonathan BaoJulie G Pilitsis
Jul 9, 2021·Biochemical and Biophysical Research Communications·Keigo TanakaHiroshi Ueda
Jul 9, 2021·Drugs & Aging·Amir Minerbi, Mary-Ann Fitzcharles

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