PMID: 2888822Oct 1, 1987

The phenotype of thymocytes derived from a single clonogenic precursor

The Journal of Immunology : Official Journal of the American Association of Immunologists
S EzineI L Weissman

Abstract

Clonogenic repopulation of the thymus of thymus-homing bone marrow cells leads to intrathymic populations representing all four major Lyt-2- and L3T4-defined phenotypes. Although all four phenotypes may be represented in a single clone, quite often a striking bias in the proportion of L3T4 single positive to Lyt-2 single positive cells may exist within a clone, but not in the host thymocytes in general. Because at any one time these clones may be located in specific subregions of the thymus (specifically cortex only, medulla only, or cortex and medulla), we propose the hypothesis that different microenvironments in the thymus might, in fact, be responsible for the predominant maturation of different single positive mature thymic subsets.

Related Concepts

Flow Cytometry
T-Lymphocyte
Cortex Bone Disorders
Adrenal Cortex Diseases
Colony-Forming Units, Hematopoietic
Entire Medulla Oblongata
T6 Antigens
Neoplasm of Uncertain or Unknown Behavior of Thymus
Thymocyte
Disease of Thymus Gland

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