The pheromone response pathway of Kluyveromyces lactis

FEMS Yeast Research
Roberto CoriaGerardo Coello

Abstract

The mating pheromone response pathway in Saccharomyces cerevisiae is one of the best understood signalling pathways in eukaryotes. Comparison of this system with pathways in other fungal species has generated surprises and insights. Cloning and targetted disruption of genes encoding components of the pheromone response pathway has allowed the attribution of specific functions to these signal transduction components. In this review we describe current knowledge of the Kluyveromyces lactis mating system, and compare it with the well-understood S. cerevisiae pathway, emphasizing the similarities and differences in the heterotrimeric G protein activity. This mating pathway is controlled positively by both the Galpha and the Gbeta subunits of the heterotrimeric G protein.

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Citations

Dec 18, 2010·Nature·Lauren N BoothAlexander D Johnson
Apr 19, 2011·Fungal Genetics and Biology : FG & B·Stephen K Jones, Richard J Bennett
Jul 15, 2015·Nature·Trevor R SorrellsAlexander D Johnson
Sep 14, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zena Hadjivasiliou, Andrew Pomiankowski
Dec 15, 2015·Cold Spring Harbor Symposia on Quantitative Biology·Isabel Nocedal, Alexander D Johnson
Mar 24, 2006·FEMS Immunology and Medical Microbiology·Antonio E PérezGerardo Guillén
Feb 23, 2019·MSphere·Golnaz RastghalamMalcolm Whiteway
Aug 27, 2021·Journal of Cell Science·Marius MusielakJürgen J Heinisch

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