The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease

Nature Medicine
G P WalshM A Horwitz

Abstract

A nonhuman primate model of tuberculosis that closely resembles human disease is urgently needed. We have evaluated the Philippine cynomolgus monkey, Macaca fasicularis, as a model of TB. Cynomolgus monkeys challenged intratracheally with extremely high doses of Mycobacterium tuberculosis (10(5) or 10(4) CFU) developed an acute, rapidly progressive, highly fatal multilobar pneumonia. However, monkeys challenged with moderate or low doses of M. tuberculosis (</=10(3) CFU) developed a chronic, slowly progressive, localized form of pulmonary TB, akin to the disease in humans, that was frequently accompanied by such clinical syndromes as ocular tuberculosis, meningitis and tuberculous spondylitis. A significant proportion of monkeys challenged with 10(2) or 10(1) CFU contained the infection in a subclinical state. The Philippine cynomolgus monkey model is an excellent model of chronic TB and provides an opportunity to study subclinical and potentially latent disease in an animal model.

References

Feb 1, 1979·American Journal of Epidemiology·L S FarerM P Meador
Sep 5, 1968·Annals of the New York Academy of Sciences·R C Good
Oct 1, 1967·American Journal of Ophthalmology·H C Donahue
Oct 1, 1967·Southern Medical Journal·E Barrett-Connor
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A HorwitzG Harth
Jun 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R WurtzB Langer
Nov 21, 1964·Nature·A BOYUM

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Citations

Sep 16, 2009·Archives of Ophthalmology·Narsing A RaoPetros C Karakousis
Jan 1, 1997·Springer Seminars in Immunopathology·D B LowrieR E Tascon
Mar 27, 2007·Immunogenetics·Shelby L O'ConnorDavid H O'Connor
Dec 25, 2008·Immunogenetics·Kevin J CampbellDavid H O'Connor
Feb 26, 2010·Pharmaceutical Research·Pavan MuttilAnthony J Hickey
Oct 13, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jing ZhangWen-Zhe Ho
Jul 3, 2013·Antiviral Research·Simon-Djamel ThibervilleXavier de Lamballerie
Jul 29, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Douglas S WalshWayne M Meyers
Dec 13, 2003·Tuberculosis·James E Gomez, John D McKinney
Mar 24, 2004·Veterinary Microbiology·R AlfonsoM A Patarroyo
Mar 12, 2003·Preventive Veterinary Medicine·Feliciano Milian SuazoRuth M Gallegos Torres
May 22, 2003·Tuberculosis·J L FlynnE Klein
May 22, 2003·Tuberculosis·S G ReedY A W Skeiky
Sep 5, 2003·The Lancet Infectious Diseases·JoAnn M TufarielloJoAnne L Flynn
Apr 3, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J Hermon-Taylor
Mar 22, 2002·Nature Reviews. Immunology·S H Kaufmann
Dec 21, 2004·Nature Reviews. Microbiology·Helena I M Boshoff, Clifton E Barry
Mar 24, 2004·Nature Reviews. Microbiology·Graham R StewartDouglas B Young
Sep 17, 2004·Nature Reviews. Microbiology·Denise M MonackStanley Falkow
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Steven G ReedYves Lobet
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Philana Ling LinJoanne L Flynn
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D N McMurray
Apr 17, 2010·The Journal of Infectious Diseases·Noton K DuttaDeepak Kaushal
Aug 12, 2003·AIDS Research and Human Retroviruses·Hassan SafiPeter F Barnes
Mar 8, 2008·ILAR Journal·Nicholas W LercheJoanne L Flynn
Mar 8, 2008·ILAR Journal·Murray B Gardner, Paul A Luciw
Aug 15, 2012·The Journal of Infectious Diseases·Rhea N ColerSteven G Reed
Oct 12, 2010·Clinical Microbiology Reviews·Arthur M Dannenberg
Jun 23, 2006·Infection and Immunity·Philana Ling LinJoanne L Flynn
Jul 22, 2009·Infection and Immunity·Philana Ling LinJoAnne L Flynn
Jun 15, 1996·BMJ : British Medical Journal·A S Malin, D B Young
May 24, 2011·Clinical & Developmental Immunology·Masaji OkadaMitsunori Sakatani
Jun 17, 2008·American Journal of Respiratory Cell and Molecular Biology·Ashwin S Dharmadhikari, Edward A Nardell
Feb 25, 2010·The Journal of Clinical Investigation·Karine LabadiePierre Roques
Apr 22, 2009·PLoS Pathogens·Crystal Y ChenZheng W Chen
Aug 3, 2012·The American Journal of Tropical Medicine and Hygiene·Gerald P WalshDouglas S Walsh

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