The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms.

Human Pathology
David M DorfmanG J Freeman

Abstract

The T cell immunoglobulin mucin (TIM) proteins are a family of cell surface phosphatidyserine receptors that are important for the recognition and phagocytosis of apoptotic cells. Because TIM-4 is expressed by macrophages and dendritic cells in human tissue, we examined its expression in a range of histiocytic and dendritic cell neoplasms and found moderate to strong immunohistochemical staining in cases of juvenile xanthogranuloma and histiocytic sarcoma, and lower level staining in interdigitating dendritic cell sarcoma, Langerhans cell histiocytosis, acute monocytic leukemia (leukemia cutis), and blastic plasmacytoid dendritic cell neoplasm (hematodermic tumor). TIM-3 was first described on activated T(H)1 cells but was recently shown to also be a phosphatidylserine receptor and mediate phagocytosis. We found TIM-3 was expressed by peritoneal macrophages, monocytes and splenic dendritic cells. We found that it, like TIM-4, is expressed in a range of histiocytic and dendritic cell neoplasms, typically with strong immunohistochemical staining. Cases of diffuse large B cell lymphoma, anaplastic large cell lymphoma, metastatic malignant melanoma, and metastatic poorly differentiated carcinoma generally exhibited negative to mini...Continue Reading

References

Aug 25, 2004·American Journal of Clinical Pathology·David M DorfmanLaurie H Glimcher
Nov 18, 2004·Pediatric Blood & Cancer·Sheila Weitzman, Ronald Jaffe
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Citations

Oct 4, 2014·Virology·Sven Moller-Tank, Wendy Maury
Oct 30, 2015·British Journal of Cancer·Qianqian ZhangLifen Gao
Jun 6, 2015·Cancer Biology & Therapy·Elisabetta Di LisoLaura Bonanno
Mar 2, 2016·Annual Review of Immunology·Susanne H BaumeisterArlene H Sharpe
Aug 8, 2015·PloS One·Frédéric GrosjeanDriss Ehirchiou
Jun 20, 2016·Seminars in Diagnostic Pathology·Fabio Facchetti, Luisa Lorenzi
Sep 4, 2012·Cellular & Molecular Immunology·Shao-Bo YangPing-Chang Yang
Dec 1, 2017·Current Opinion in Organ Transplantation·Martina M McGrath
Jun 15, 2016·The American Journal of Surgical Pathology·Anne M StowmanMark R Wick
Apr 18, 2020·Frontiers in Immunology·Wen LiuLifen Gao
Apr 1, 2020·Cellular & Molecular Biology Letters·Mehri Bemani NaeiniAmirhossein Sahebkar

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